55791-76-9Relevant academic research and scientific papers
Study of the microwave-assisted hydrolysis of nitriles and esters and the implementation of this system in rapid microwave-assisted Pd-catalyzed amination
Van Baelen, Gitte,Maes, Bert U.W.
, p. 5604 - 5619 (2008/09/21)
Microwave-assisted hydrolysis of benzonitriles and methyl benzoates has been studied using a toluene/concd aq KOH two phase system in the presence and absence of phase transfer catalyst. Conditions to allow and avoid smooth hydrolysis could be identified. Based on the latter, the first microwave protocol which allows the rapid Pd-catalyzed amination of aliphatic amines with chlorobenzenes containing sensitive functional groups has been developed.
Solid-phase synthesis of oligo(p-benzamide) foldamers
Koenig, Hannah M.,Abbel, Robert,Schollmeyer, Dieter,Kilbinger, Andreas F. M.
, p. 1819 - 1822 (2007/10/03)
A coupling protocol has been developed which allows the synthesis of oligo(p-benzamide)s on solid support. Aromatic carboxylic acids are activated in situ with thionyl chloride and used to acylate secondary aromatic amines. N-p-Methoxy benzyl (PMB) as wel
NORVALINE DERIVATIVE AND METHOD FOR PREPARATION THEREOF
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Page/Page column 30; 55, (2008/06/13)
Norvaline derivative of the formula [I] or pharmaceutically acceptable salt thereof, method for preparing the same, pharmaceutical composition containing the same, and use of said compound for inhibiting transporting activity of glycine transporter type 2 (GlyT2). [wherein X is -CH2-, -O-, -S- or single bond; Ar is optionally substituted aryl or lower cycloalkyl; n is 0 to 2; R1 and R2 are (i) each is hydrogen or lower alkyl; (ii) R1 and R2 are combined to form lower alkylene; or (iii) R1 is hydrogen or lower alkyl and R2 is combined with R4 or R6 to form lower alkylene; R3 and R4 are (i) each is hydrogen or lower alkyl; (ii) R3 and R4 are combined to form lower alkylene; or (iii) R3 is hydrogen or lower alkyl and R4 is combined with R2 or R6 to form lower alkylene; R is or -OR7; R 5 and R6 are (i) each is optionally substituted lower alkyl, or hydrogen; (ii) R5 and R6 are combined to form aliphatic 5- to 6-membered heterocyclic group; or (iii) R5 is optionally substituted lower alkyl or hydrogen and R6 is combined with R2 or R4 to form lower alkylene; R7 is lower alkyl.
Liquid Crystalline 4-Cyanobiphenyl-4-Alkylaminobenzoates
Gureviciene, J.-J.,Adomenas, P.
, p. 177 - 180 (2007/10/02)
The mesomorphic and dielectric properties of homolo new compounds 4-cyanobiphenyl-4-alkylaminobenzoates are presented.
Potential antiatherosclerotic agents. 2. (Aralkylamino)- and (alkylamino)benzoic acid analogues of cetaben
Albright,DeVries,Largis,Miner,Reich,Schaffer,Shepherd,Upeslacis
, p. 1378 - 1393 (2007/10/02)
The syntheses of a series of (aralkylamino)- and (alkylamino)benzoic acids, as well as the corresponding esters and sodium salts, are described. The compounds were evaluated in vivo in rats for serum sterol and triglyceride lowering activity and in vitro
