55792-49-9Relevant academic research and scientific papers
Synthesis and biological evaluation of novel N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives as PTP1B inhibitors
Tong, Yuan Feng,Zhang, Pei,Chen, Feng,Hao, Ling Hua,Ye, Fei,Tian, Jin Ying,Wu, Song
scheme or table, p. 1415 - 1418 (2011/10/09)
Based on the fact that petroselinic acid showed good inhibitory activity (IC50=6.99μmol/L) against protein tyrosine phophatase 1B(PTP1B) in vitro, a series of novel N-(alkoxyphenyl)-aminocarbonylbenzoic acid derivatives were designed and synthesized. The results indicated that most of the derivatives showed more potent activities against PTP1B. Especially, compound 13 had obvious activity with an IC50 of 106nmol/L in vitro.
Modulating large-area self-assembly at the solid-liquid interface by pH-mediated conformational switching
Piot, Luc,Meudtner, Robert M.,Malah, Tamer El,Hecht, Stefan,Samori, Paolo
supporting information; experimental part, p. 4788 - 4792 (2009/12/05)
The two-dimensional ordering of molecules adsorbed on surfaces at the solid-liquid interface that are capable to undergo large conformational changes upon the application of an external chemical stimulus was investigated. Large-area self-assembly at the solid-liquid interface was modulated using pH-mediated conformational switching. Scanning tunneling microscopy (STM) visualization was attempted for the first time to examine and visualize large conformational changes of a responsive molecular building block resulting in its altered self-assemble behavior at the solid-liquid interface. It was observed that protonation can work effectively to overcome the repulsive interaction between certain 2,6-bis (1-aryl-1,2,3-triazol-4-yl) pyridine (BTP) molecules and also in the formation of an extended conformation on a HOPG surface. The method has encouraged the efforts towards development of reversible pH triggered switches at the solid-liquid interface.
