55801-97-3Relevant academic research and scientific papers
Design, synthesis, antibacterial, and antitumor activity of linear polyisocyanide quaternary ammonium salts with different structures and chain lengths
Fu, Shuang,Hou, Peng,Liu, Jun,Liu, Lijia,Zhang, Hongguang
, (2021/09/28)
The development of organic polymer materials for disinfection and sterilization is thought of as one of the most promising avenues to solve the growth and spread of harmful microorgan-isms. Here, a series of linear polyisocyanide quaternary ammonium salts (L-PQASs) with different structures and chain lengths were designed and synthesized by polymerization of phenyl isocyanide monomer containing a 4-chloro-1-butyl side chain followed by quaternary amination salinization. The resultant compounds were characterized by1H NMR and FT-IR. The antibacterial activity of L-PQASs with different structures and chain lengths against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was evaluated by determining the minimum inhibitory concentrations (MICs). The L-POcQAS-M50 has the strongest antimicrobial activity with MICs of 27 μg/mL against E. coli and 32 μg/mL against S. aureus. When the L-PQASs had the same polymerization degree, the order of the antibacterial activity of the L-PQASs was L-POcQAS-Mn > L-PBuQAS-Mn > L-PBnQAS-Mn > L-PDBQAS-Mn (linear, polyisocyanide quaternary ammonium salt, monomer, n = 50,100). However, when L-PQASs had the same side chain, the antibacterial activity reduced with the increase of the molecular weight of the main chain. These results demonstrated that the antibacterial activity of L-PQASs was dependent on the structure of the main chain and the length of the side chain. In addition, we also found that the L-POcQAS-M50 had a significant killing effect on MK-28 gastric cancer cells.
Alkynylcopper(I) complexes with PPh3 ligands. Preparation, structure, and alkynyl ligand transfer to palladium(II) complexes
Osakada, Kohtaro,Takizawa, Tadashi,Yamamoto, Takakazu
, p. 3531 - 3538 (2008/10/09)
Reactions of copper alkoxide complexes Cu(OCH(CF3)2)(PPh3)3, Cu(OCHPh2)(PPH3)3, and [Cu(OPh)(PPh3)2]2 with HC≡CCOOR (R = Me, Et, tBu) give alkynyl copper complexes formulated as Cu2(C≡CCOOR)2(PPh3)3 (1, R = Me; 2, R = Et; 3, R = tBu). The 1H, 13C{1H}, and 31P{1H} NMR spectra agree with the structures containing two bridging alkynyl ligands that are coordinated to Cu(PPh3) and to Cu(PPh3)2 units. The copper alkoxide complexes react with alkynes HC≡CSiMe3, HC≡CPh, and HC≡CC6H4-p-Me to give alkynylcopper(I) complexes [Cu(C=CR′)(PPh3)]4 (4, R′ = SiMe3; 5, R′ = Ph; 6, R′ = C6H4-p-Me). X-ray crystallography of 4·Et2O reveals a molecular structure containing a cubane-like core composed of four copper(I) centers bridged by four alkynyl ligands, each of which is coordinated to three Cu centers as a μ3-η1:η1:η1-ligand. Complex 5 undergoes ligand substitution by HC≡CCOOEt in the presence of PPh3 to give 2. Complexes 1-6 react with PdCl2(PEt3)2 to cause alkynyl ligand transfer from Cu to Pd. Reactions of 1-3 with 0.5 equiv of PdCl2(PEt3)2 in the presence of PPh3 give trans-Pd(C≡CCOOR)2(PEt3)2 accompanied by formation of CuCl(PPh3)3. Complex 4 undergoes alkynyl ligand transfer to give trans-PdCl(C≡CSiMe3)(PEt3)2 exclusively, while similar reactions of 5 and 6 give mixtures of trans-Pd(C≡CAr)2(PEt3)2 and trans-PdCl(C≡CAr)(PEt3)2 (Ar = Ph, C6H4-p-Me).
