55807-82-4Relevant academic research and scientific papers
A Simple Transformation of 1-(Isoxazol-3-yl)ureas to 5-(2-oxoalkyl)-2,4-dihydro-3H-1,2,4-triazol-3-ones through Base-Promoted Boulton-Katritzky Rearrangement
Liu, Jisheng,Chen, Chen,Kotagiri, Rajendraprasad,Yang, Wenqiang,Cai, Qian
, p. 481 - 484 (2019)
2,4-Dihydro-3H-1,2,4-triazol-3-ones are a class of biologically important heterocycles. A novel and simple synthesis of such structures is developed. The method is through a base-promoted Boulton-Katritzky-type rearrangement of 1-(isoxazol-3-yl)ureas and is highly efficient for the formation of 2,4-dihydro-3H-1,2,4-triazol-3-ones. (Figure presented.).
