55809-36-4

Basic information

• Product Name: 3-Amino-5-tert-butylisoxazole
• Synonyms: TIMTEC-BB SBB005492;5-TERT-BUTYLISOXAZOL-3-AMINE;5-TERT-BUTYL-ISOXAZOL-3-YLAMINE;5-(1,1-dimethylethyl)-3-isoxazolamine;3-AMINO-5-TERT-BUTYLISOXAZOLE;3-AMINO-5-T-BUTYLISOXAZOLE;3-Amino-5-tert-butylisoxazole,97%;3-Amino-5-tert-butylisoxazole 97%
• CAS NO: 55809-36-4
• Molecular Formula: C₇H₁₂N₂O
• Molecular Weight: 140.18
• EINECS: -0
• Product Categories: Oxazole&Isoxazole;Building Blocks;Heterocyclic Building Blocks;Isoxazoles;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 55809-36-4.mol
• Article Data: 13

Chemical Properties

• Melting Point: 110-114 °C
• Boiling Point: 248.1 °C at 760 mmHg
• Flash Point: 103.9 °C
• Appearance: /
• Density: 1.042 g/cm³
• Vapor Pressure: 0.0247mmHg at 25°C
• Refractive Index: 1.496
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 2.37±0.10(Predicted)
• BRN: 1100990
• CAS DataBase Reference: 3-Amino-5-tert-butylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-5-tert-butylisoxazole(55809-36-4)
• EPA Substance Registry System: 3-Amino-5-tert-butylisoxazole(55809-36-4)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-37/38-36
• Safety Statements: 26-36-37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 55809-36-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 55809-36-4 differently. You can refer to the following data:
1. Amination of aryl bromides catalyzed by Pd(dba)3 (Aldrich Catalog No. 328774) and Xantphos (Aldrich Catalog No. 526460).1
2. Amination of aryl bromides catalyzed by Pd(dba)3 (Aldrich Catalog No. 328774) and Xantphos (Aldrich Catalog No. 526460).
3. 3-Amino-5-tert-butylisoxazole is a degradation product of herbicide isouron.

InChI:InChI=1/C7H12N2O/c1-7(2,3)5-4-6(8)9-10-5/h4H,1-3H3,(H2,8,9)

Upstream product

• 59997-51-2 trimethylacetylacetonitrile 
• 149590-33-0 β-Hydroxy-γ,γ-dimethylpentanenitrile 
• 3938-95-2 2,2-dimethyl-propanoic acid ethyl ester 
• 59669-59-9 5-amino-3-tert-butylisoxazole 
• 15673-05-9 4,4-dimethylvaleronitrile 
• 55807-46-0 1-(5-tert-butylisoxazol-3-yl)-3-methylurea 
• 55808-13-4 (5-tert-butyl-isoxazol-3-yl)-carbamic acid methyl ester 
• 74011-69-1 N-(5-t-butyl-3-isoxazolyl)-2-methylvaleramide 
• 136320-07-5 N-(3-tert-butylisoxazol-5-yl)-5-tert-butyl-3-aminoisoxazole 
• 121449-41-0 4,4,-dimethyl-3-oxopentaneamidoxime 
• 55861-78-4 1,1-dimethyl-3-(5-tert-butyl-3-isoxazolyl)urea 

Downstream Products

• 81479-48-3 phenyl (5-(tert-butyl)isoxazol-3-yl)carbamate 
• 120771-20-2 5-tert-butyl-4-methyl-1,2-oxazol-3-amine 
• 1020673-22-6 (5-tert-butyl-isoxazol-3-yl)-[5-((S)-2-phenyl-morpholin-4-ylmethyl)-pyridin-2-yl]-amine 
• 55861-78-4 1,1-dimethyl-3-(5-tert-butyl-3-isoxazolyl)urea 
• 55809-27-3 N-(5-(t-butyl)isoxazol-3-yl)-2-chloroacetamide 

Relevant articles and documents

Preparation method 3 -amino -5 -alkyl isoxazole

The invention discloses a preparation method of 3-amino-5-alkyl isoxazole, realizes preparation through two steps and belongs to the technical field of organic chemistry. By starting from easily obtained aldehyde, after the addition with acetonitrile under the existence of metal alkali, an intermediate of hydroxy nitrile is obtained; then, the hydroxy nitrile reacts with hydroxylamine; ring closing reaction is performed under the existence of Lewis acid; after autoxidation, the 3-amino-5-alkyl isoxazole is obtained. The raw materials in the reaction process are very commons; chloroform or tetrachloromethane in a traditional method is avoided; potential industrial amplification prospects are realized.

THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES

Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases.

THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES

Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases