558449-13-1

Upstream product

• 327040-08-4 (E)-N-benzyliden-4-methylbenzenesulfinamide 
• 3167-63-3 diethyl chloromethylphosphonate 
• 220586-54-9 diethyl(-)-(2S,3R)-(3-phenyl-2-H-aziridin-2-yl) phosphonate 
• 220586-49-2 diethyl(-)-S-(3-phenyl-2-H-azirin-2-yl) phosphonate 
• 98-59-9 p-toluenesulfonyl chloride 
• 260980-56-1 diethyl(-)-(2S,3R)-[3-phenyl-1-p-toluenesulfonyl-aziridin-2-yl] phosphonate 

Downstream Products

• 68839-08-7 (S)-(1-Amino-2-phenylethyl)phosphonsaeure-diethylester 

Relevant academic research and scientific papers

Asymmetric synthesis of 2H-aziridine phosphonates, and α- or β-aminophosphonates from enantiomerically enriched 2H-azirines

A simple and efficient method for asymmetric synthesis of 2H-azirine-2-phosphonates 6 is described. The key step is a base-mediated Neber reaction of p-toluenesulfonyloximes 4 derived from phosphonates. Triethylamine 5, alkaloids 7 and solid-phase bound a

Asymmetric synthesis of aziridinyl phosphonates using Darzens-type reaction of chloromethyl phosphonate to chiral sulfinimines

Darzens-type reaction of chloromethyl phosphonate with (S)-(+)-N- sulfinimines gave (Ss, 2S, 3R)-diethyl 3-aryl-2-N-(p- toluenesulfinyl)aziridinylphosphonate (3) in good yields.