55846-84-9Relevant academic research and scientific papers
Regioselective synthesis of 1,3,5- and 1,3,4,5-substituted pyrazoles via acylation of N-Boc-N-substituted hydrazones
Tinarelli, Alessandro,Righi, Paolo,Rosini, Goffredo,Andreotti, Daniele,Profeta, Roberto,Spada, Simone
experimental part, p. 612 - 617 (2011/03/19)
Acylation of N-Boc-N-methylhydrazones followed by TFA treatment affords regioselective access to substituted pyrazoles. Both regioisomers of 1-methyl-3,5-disubstituted-1H-pyrazoles can be selectively obtained. This procedure can also be employed for the r
Multi-Step synthesis by using modular flow reactors: The preparation of Yne-Ones and their use in heterocycle synthesis
Baxendale, Ian R.,Schou, Seren C.,Sedelmeier, Joerg,Ley, Steven V.
supporting information; experimental part, p. 89 - 94 (2010/03/03)
"Chemical Equation Presented" Multi-step in flow: The palladium-catalysed acylation of terminal alkynes for the synthesis of yne-ones as well as their further transformation to various heterocycles in a continuous-flow mode is presented. Furthermore, an extension of the simple flow configuration that allows for easy batch splitting and the generation of a heterocyclic library is described (see scheme).
