558483-99-1Relevant academic research and scientific papers
Modular strategy for the synthesis of functionalized aryl-fused azabicyclo[2.2.2]octanes via sequential Cu/Pd/Ru catalysis
McCormick, Lucas F.,Malinakova, Helena C.
, p. 8809 - 8815 (2013/09/24)
Aryl-fused 2-azabicyclo[2.2.2]octanes were prepared by a novel sequence of Cu-catalyzed three-component coupling of diversely substituted N-benzyl o-bromoaryl imines with methacryloyl chloride and vinyltributyl stannane followed by Pd-catalyzed Heck annulation. Subsequent diversification of the aryl-fused 2-azabicyclo[2.2.2]octane core was achieved by attaching a flexible linker and a potential second pharmacophore via Ru-catalyzed cross-metathesis and a nucleophilic substitution.
Convenient synthesis of 2-benzazepines via radical cyclization
Kamimura, Akio,Taguchi, Yohei,Omata, Yoji,Hagihara, Masahiko
, p. 4996 - 4998 (2007/10/03)
Synthesis of 2-benzazepines was readily achieved via 7-endo radical cyclization of N-o-bromobenzylitaconamides or N-o-bromobenzylmethacrylamides which were prepared in two steps from commercially available benzaldehydes, amines, and α,β-unsaturated acids.
