55851-35-9Relevant academic research and scientific papers
Preparation method of 4-(4-aminophenyl)-3-molindone
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Paragraph 0069; 0087; 0094; 0095; 0096, (2018/11/03)
The invention provides a preparation method of 4-(4-aminophenyl)-3-molindone. The preparation method has the advantages that reaction steps with high risk and high environmental pressure are omitted,especially the use of mixed acid and chloroacetyl chloride is avoid, so that the pressure of environmental protection is reduced; in addition, the use of strong oxidants such as potassium permanganateis avoided, so that the production of by-products is reduced, the synthesis yield is high, the product quality is good and the purification of reaction post treatment is facilitated; besides, all thesteps related in the reaction process are easy to carry out, so that the reaction in which passivation effect of functional groups and the like are difficult to generate in an existing method is avoided, for example, the route which takes p-nitroaniline as a raw material to carry out substitution reaction is almost impossible to perform; besides, the selected raw materials such as p-fluoronitrobenzene and bromoethylamine hydrobromide, disclosed by the invention are easy to obtain; compared with the molindone and other raw materials involved in the existing method, the preparation method is low in price and is suitable for industrialized production.
Two-photon probes for Zn2+ ions with various dissociation constants. Detection of Zn2+ ions in live cells and tissues by two-photon microscopy
Danish, Isravel Antony,Lim, Chang Su,Tian, Yu Shun,Han, Ji Hee,Kang, Min Young,Cho, Bong Rae
, p. 1234 - 1240 (2011/12/15)
A series of Zn2+-selective two-photon fluorescent probes (AZnM1-AZnN) that had a wide range of dissociation constants (Kd TP=8 nm-12 νM) were synthesized. These probes showed appreciable water solubility (>3 νM), cell permeability, high photostability, pH insensitivity at pH>7, significant two-photon action cross-sections (86-110 GM) upon complexation with Zn2+, and can detect the Zn2+ ions in HeLa cells and in living tissue slices of rat hippocampal at a depth of >80 νm without mistargeting and photobleaching problems. These probes can potentially find application in the detection of various amounts of Zn 2+ ions in live cells and intact tissues. A-tissue a-tissue, we all fall down: A series of Zn2+-ion selective two-photon fluorescent probes with a wide range of dissociation constants (KdTP=8 nM-12 νM) were developed to be able to detect the Zn2+ ions in live cells and intact tissues at a depth of>80 νm without the drawbacks of mistargeting and photobleaching.
Synthesis of benzannulated N-heterocycles by a palladium-catalyzed C-C/C-N coupling of bromoalkylamines
Thansandote, Praew,Raemy, Manuel,Rudolph, Alena,Lautens, Mark
, p. 5255 - 5258 (2008/09/17)
(Chemical Equation Presented) A palladium-catalyzed domino intermolecular alkylation/intramolecular amination of functionalized aryl iodides represents a new strategy for the synthesis of benzannulated N-heterocycles, affording functionalized indolines an
Sulfur-containing secondary para-phenylenediamines dye compositions comprising such para-phenylenediamines, processes, and uses thereof
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Page/Page column 25, (2010/02/15)
The present disclosure relates to a novel family of sulfur-containing secondary para-phenylenediamines, to processes for preparing them, to compositions for dyeing keratin fibers, for example keratin fibers such as the hair, comprising, in a suitable dyeing medium, at least such one sulfur-containing secondary para-phenylenediamine. The present disclosure also relates to processes for dyeing keratin fibers with the compositions according to the present disclosure and to multi-compartment dyeing kits containing such compositions.
