55875-47-3

Upstream product

• 16518-62-0 3-bromo-N,N-dimethylaniline 
• 59142-68-6 2-bromo-4-fluorobenzaldehyde 
• 124-40-3 dimethyl amine 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 207789-61-5 4-(dimethylamino)-2-((trimethylsilyl)ethynyl)benzaldehyde 
• 85103-74-8 N'-[4-(2-Bromo-4-dimethylamino-benzylamino)-2,6-dichloro-phenyl]-N,N-dimethyl-formamidine 
• 85103-75-9 N'-(2-Bromo-4-dimethylamino-benzyl)-2,6-dichloro-benzene-1,4-diamine 

Relevant academic research and scientific papers

"covalent-Assembly"-Based Fluorescent Probe for Detection of a Nerve-Agent Mimic (DCP) via Lossen Rearrangement

The highly selective and sensitive fluorescence "light-up" probe, 5′-(dimethylamino)-2′-formyl-N-hydroxy-[1,1′-biphenyl]-2-carboxamide(PTS), has been fabricated for the nerve-agent mimic diethyl chlorophosphate (DCP). The probe is designed by combining tw

Asymmetric bismuth-rhodamines as an activatable fluorogenic photosensitizer

Bismuth-rhodamine compounds stand out for their unique excitable photosensitizing properties and concomitant fluorescence; however, further knowledge of the structure-property relationship is required to expand the scope of their practical application. Wi

Design, synthesis, and biological evaluation of novel triazoloquinazolinone derivatives as SHP2 protein inhibitors

A novel series of triazoloquinazolinone derivatives were designed, synthesised, and evaluated for their in vitro biological activities against the SHP2 protein. Moreover, some compounds were evaluated against A375 cells. The results revealed that target compounds possessed moderate to excellent inhibitory activity against SHP2 protein, whereas compounds 12f, 12l, 12j, 17e, and 17f have strong antiproliferative activity on A375 cells. The compound 12l showed remarkable cytotoxicity against A375 cells and a strong inhibitory effect against SHP2 protein when compared with SHP244. The structure-activity relationships (SARs) indicated that electron-donating groups (EDGs) on phenyl rings are beneficial for improving the antitumor activity; compounds with a hydroxyl substituent at the 2-position of phenyl ring exhibited superior activities than compounds with a substituent at the 4-position. In addition, compound 12l displayed improved physicochemical properties as well as metabolic stability compared to SHP244. Our efforts identified 12l as a promising SHP2 protein inhibitor, warranting its further investigation.

DEEP RED FLUORESCENT PROBE

A near-infrared fluorescent probe has fluorescence in the near-infrared region. Like CaSiR-1, the probe has rhodamines as the fluorescent mother nucleus and accumulates in the cytoplasm. The probe makes it possible to visualize concentration fluctuations

Hydrogen-bonding-induced bathochromic effect of Si-coumarin and its use in monitoring adipogenic differentiation

Introduction of a heteroatom into a fluorophore was carried out for coumarin through a replacement of its bridging oxygen atom with a silicon atom. The maximum-emission wavelength of Si-coumarin (SiC B) bathochromically shifted from 426 nm in cyclohexane to 626 nm in water. The adipogenic differentiation processes in mesenchymal stem cells were monitored using SiC B.

A class of silicon-substituted coumarin derivatives, and synthesis method thereof

The invention discloses a class of silicon-substituted coumarin derivatives, which have a structure represented by a formula I, wherein R is a nitrogen methyl group, a nitrogen ethyl group, a nitrogenhydrogen ethyl group, a nitrogen four-membered ring, a nitrogen ethyl five-membered ring or a nitrogen ethyl six-membered ring. According to the preparation, aniline is subjected to a formylation reaction by using a corresponding aromatic amine as a starting raw material and using phosphorus oxychloride and DMF as reaction reagents; the Ylide reaction of the aldehyde group is performed by using n-butyl lithium as a reaction reagent and using anhydrous THF as a solvent; a lithiation reaction is performed by using n-butyl lithium as reaction reagent to obtain a dimethyl silicon substituted intermediate; and finally diene is subjected to a double decomposition reaction under the catalysis of a Grubbs II catalyst to achieve the intramolecular ring closure, and oxidation is performed with selenium dioxide to obtain the final product. According to the present invention, a class of the novel silicon-substituted coumarin derivatives are synthesized, are sensitive to environmental polarity, and can be used for monitoring the activity of cells in vivo.

Synthesis of unsymmetrical Si-rhodamine fluorophores and application to a far-red to near-infrared fluorescence probe for hypoxia

Si-Rhodamines are bright fluorophores with red to near-infrared (NIR) emission, and are widely used for fluorescence imaging of biological phenomena. Here, in order to extend the scope of Si-rhodamine fluorophores, we established a versatile synthesis of unsymmetrical Si-rhodamines. To illustrate its value, we used one of these new fluorophores to synthesize a far-red to NIR fluorescence probe for hypoxia, and showed that it can visualize hepatic ischemia in mice in vivo.

The effects of bromine atoms on the photophysical and photochemical properties of 3-cinnamoylcoumarin derivatives

Eight coumarin derivatives (T1-T8) with or without modification using one or two bromine atoms were synthesized through the aldol condensation reaction. Their photophysical, photochemical and electrochemical properties were investigated. It was shown that

Fluorescent dye having phenazine condensed structure and synthesis method of same

The invention discloses a fluorescent dye having phenazine condensed structure, of which the structural formula is represented as one of the formulas (I) to (IV). The fluorescent dye having phenazinecondensed structure is prepared through steps of: reacti

General method for nucleophilic aromatic substitution of aryl fluorides and chlorides with dimethylamine using hydroxide-assisted decomposition of N,N-dimethylforamide

A practical and convenient procedure for the nucleophilic aromatic substitution of aryl fluorides and chlorides with dimethylamine was developed using a hydroxide-assisted thermal decomposition of N,N-dimethylforamide. These conditions are tolerant of nitro, nitrile, aldehyde, ketone, and amide groups but will undergo acyl substitution to form amides for methyl esters and acyl chlorides. Isolated yields of the products range from 44% to 98%, with the majority being greater than 70% for 17 examples.