55877-89-9

Upstream product

• 578-57-4 2-bromoanisole 
• 104846-98-2 3-(2-Methoxy-phenyl)-butyric acid methyl ester 
• 579-74-8 2-Methoxyacetophenone 
• 529-28-2 4-iodoanisol 
• 513-42-8 3-hydroxy-2-methyl-1-propene 

Downstream Products

• 1353093-49-8 (+/-)-2-[4-(tert-butyl)benzyl]-3-methylchroman 
• 1353093-34-1 2-(2-methylbut-3-en-1-yl)phenol 
• 18272-81-6 1-methoxy-2-(pent-4-en-2-yl)benzene 

Relevant academic research and scientific papers

Pd-Catalyzed Arylation of 1,2-Amino Alcohol Derivatives via β-Carbon Elimination

Herein, we describe a Pd-catalyzed arylation of 1,2-amino alcohols with aryl halides enabled by a retroallylation manifold. This protocol constitutes a new entry point to β-arylated aldehydes via the intermediacy of in situ generated enamine intermediates. The protocol is characterized by its exquisite regioselectivity profile and broad substrate scope including challenging substrate combinations even in an enantioselective manner.

ANTI-HCMV COMPOSITIONS AND METHODS

This document relates to compounds useful as agents for preventing or treating human cytomegalovirus (HCMV) infections.

Synthesis of chromans via Pd-catalyzed alkene carboetherification reactions

A new method for the construction of 2-substituted and 2,2-disubstituted chromans via Pd-catalyzed carboetherification reactions between aryl/alkenyl halides and 2-(but-3-en-1-yl)phenols is described. These reactions effect formation of a C-O bond and a C-C bond to afford the chroman products in good yield, and also provide stereoselective access to tricyclic chroman derivatives.

Generality and Mechanism of Homobenzylic-Homoallylic Hydrogenolysis of 5-Aryl-4,5-dihydro-1,3-dioxepins

Birch reduction of several 5-aryl-4,5-dihydro-1,3-dioxepins gave rise to 3-arylbutanal in moderate to good yields by hydrogenolytic cleavage of the homobenzylic-homoallylic carbon-oxygen bond when the benzylic-allylic carbon is tertiary.However, the reaction did not take place when the benzylic-allylic carbon is quaternary.Moreover, the reaction was found to proceed with complete racemization at the benylic-allylic center indicating a concurrent elimination-reduction pathway to be involved.