55878-80-3Relevant articles and documents
Conformationally rigid N-acyl-5-alkyl-L-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors
Wallen, Erik A. A.,Christiaans, Johannes A. M.,Saarinen, Taija J.,Jarho, Elina M.,Forsberg, Markus M.,Venaelaeinen, Jarkko I.,Maennistoe, Pekka T.,Gynther, Jukka
, p. 3611 - 3619 (2007/10/03)
In the N-acyl-L-prolyl-pyrrolidine type of prolyl oligopeptidase inhibitors the L-prolyl group was replaced by different 5-alkyl-L-prolyl groups, resulting in a series of N-acyl-5-alkyl-L-prolyl-pyrrolidines. Since N-amides of 5-alkyl-L-prolines are conformationally more rigid than those of L-proline, the main objective was to make more rigid prolyl oligopeptidase inhibitors. In the series of compounds where the N-acyl group was a Boc group, the 5(R)-tert-butyl group increased the potency strongly. A similar effect was not observed for the 5(S)-tert-butyl group. In the series of compounds where the N-acyl group was a 4-phenylbutanoyl group, the 5(R)-tert-butyl, 5(R)-methyl and 5(S)-methyl groups did not have an effect on the potency [the 5(S)-tert-butyl group was not tested in this series]. As an additional effect, the 5-tert-butyl groups increased the log P of the compounds 1.5 log units, which might be beneficial when targeting the compounds to the brain.
Total syntheses of novel dideoxynucleoside analogues using chiral amino acids
Balayiannis,Karigiannis,Gatos,Papaioannou,De Clercq
, p. 6191 - 6194 (2007/10/03)
N-Tritylated L- and D-methionine and L-glutamic acid were used to obtain novel chiral iso-dideoxynucleoside analogues incorporating a tetrahydrofuranyl or a tetrahyropyranyl ring as the pseudosugar part, and at positions 2 and 3 of the ring an hydroxyethyl group and thymine or adenine, respectively. (C) 2000 Elsevier Science Ltd.
