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Topyrramide, also known as 2-(4-pyrrolidinyl)pyrimidin-5-ol, is a chemical compound with the molecular formula C8H12N4O. It is a white crystalline solid that is soluble in water and has a molecular weight of 184.21 g/mol. Topyrramide is a potent and selective inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH), which plays a crucial role in the de novo pyrimidine synthesis pathway. This enzyme is essential for the proliferation of rapidly dividing cells, such as cancer cells and certain pathogens. By inhibiting DHODH, Topyrramide can potentially suppress the growth of cancer cells and treat various diseases caused by pathogens. Its mechanism of action makes it a promising candidate for the development of novel therapeutic agents in oncology and antimicrobial chemotherapy.

5588-38-5

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5588-38-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5588-38-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,5,8 and 8 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5588-38:
(6*5)+(5*5)+(4*8)+(3*8)+(2*3)+(1*8)=125
125 % 10 = 5
So 5588-38-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H16N2O3S/c1-10-4-6-11(7-5-10)18(16,17)13-12(15)14-8-2-3-9-14/h4-7H,2-3,8-9H2,1H3,(H,13,15)

5588-38-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(4-methylphenyl)sulfonylpyrrolidine-1-carboxamide

1.2 Other means of identification

Product number -
Other names (pyrrolidine-1-carbonyl)-(toluene-4-sulfonyl)-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5588-38-5 SDS

5588-38-5Downstream Products

5588-38-5Relevant academic research and scientific papers

Synthesis, structural characterization and in vivo anti-diabetic evaluation of some new sulfonylurea derivatives in normal and silicate coated nanoparticle forms as anti-hyperglycemic agents

Sroor, Farid M.,Abbas, Samir Y.,Basyouni, Wahid M.,El-Bayouki, Khairy A.M.,El-Mansy, Mohamed F.,Aly, Hanan F.,Ali, Sanaa A.,Arafa, Azza F.,Haroun, Ahmed A.

, (2019/09/30)

Series of new sulfonylurea derivatives (gliclazide analogues) was synthesized and characterized. Thus, p-tolylsulfonylisocyanate was left to react with different amino derivatives under mild conditions to afford the desired sulfonylurea derivatives 1–5. T

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