55898-07-2

Usage

Cytotoxicity

IC50 (μg/mL): 2.45 (HeLa), 2.43 (KB-3-1),2.36 (NCI-H460),1.90 (PC3),2.77(MCF-7),1.59 (K562)(Wu et al. 2014)

Upstream product

• 79593-19-4 (+)-(4aS,10aS)-6-acetyl-7-isopropyl-1,1,4a-trimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene 
• 19407-28-4 ar-abietatriene 
• 15340-79-1 ferruginol acetate 
• 514-62-5 ferruginol 
• 64199-80-0 O-methyl ferruginol 
• 901-41-7 sugiol methylether 
• 269719-14-4 (4aS,10aS)-7-Isopropyl-6-methoxy-1,1,4a-trimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-9-ol 
• 70614-86-7 (4aS,10aS)-7-isopropyl-6-methoxy-1,1,4a-trimethyl-1,2,3,4,4a,10a-hexahydrophenanthrene 

Relevant academic research and scientific papers

ABIETANES AND KAURANES FROM LEAVES OF CRYPTOMERIA JAPONICA

Totarol, 14-abietanes, two secoabietanes and four ent-kaurane derivatives were isolated from the leaves of Cryptomeria japonica.The new compounds included 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one, 6β-hydroxyferruginol, 7α,8α-epoxy-6α-hydroxyabieta-9(11),13-dien-12-one, (5R,10S)-12-methoxyabieta-6,8,11,13-tetraene, ent-kaur-15-en-17-al and (+)-16-acetylkaurane-16,17-diol.Their structures were determined by chemical and spectral methods.

New strategy toward the diverted synthesis of oxidized abietane diterpenes via oxidation of 6,7-dehydroferruginol methyl ether with dimethyldioxirane

A series of oxidized abietane diterpenes have been synthesized from 8,11,13-abietanotriene. The reaction of 6,7-dehydroferruginol methyl ether with dimethyldioxirane (DMDO) was carried out under various conditions. In all cases, the oxidation of positions