55901-92-3Relevant academic research and scientific papers
The use of 4-(3,4-dichlorophenyl)-4-oxo-2-(4-antipyrinyl)-butanoic acid in the preparation of some new heterocyclic compounds with expected biological activity
Sayed,Hamed,Meligi,Boraie,Shafik
, p. 322 - 332 (2007/10/03)
Reaction of 4-oxo-4-(3,4-dichlorophenyl)-2-butenoic acid (1) with antipyrin (2) gave the corresponding butanoic acid 3. Reaction of 3 with hydrazines gave the pyridazinone derivatives 5a,b. Compounds 5a,b were used to prepare the corresponding dithio derivatives. Reaction of 5a with POCl3 unexpectedly gave the chloropyridazine derivative 7, which is used to prepare the corresponding thio derivative. The hitherto unknown reactions of this chloro derivative with 2-amino-3-carbethoxy-4,5-dimethylthiophene and 2-amino-3-carbethoxy tetrahydrobenzothiophene have now been described. The behaviour of the chloro derivative toward hydrazine hydrate, sodium azide and anthranilic acid was also studied. Some of the new compounds showed antimicrobial and antifungal activities.
BIOLOGICALLY ACTIVE THIONES DERIVED FROM PYRIDAZINONES
El-Hashash, M. A.,Soliman, F. M.,Amine, M. S.,Morsi, M.
, p. 299 - 304 (2007/10/02)
A number of pyridazin-3-thione (II), some hydrazinopyridazine derivatives (III) and its Schiff base (IV) have been prepared. α-(3-Thiopyridazinyl)-β-aroylpropionic acids (VI) have also been synthesized.Structural evidences are discussed.The antibacterial activity of these compounds has been studied.
Process for producing antifungal oyridazinone derivatives
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, (2008/06/13)
Compounds of formula (I): STR1 [wherein R1 and R3 represent hydrogen or halogen atoms, R2 represents a hydrogen or halogen atom or a lower alkyl or alkoxy group (provided R1, R2 and R3 are
Substituted phenyl-1,2,4-triazolo[2,3-b]pyridazin-3(2H)ones as anti-asthma agents
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, (2008/06/13)
Substituted phenyl-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-ones, useful as anti-asthma agents.
Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
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, (2008/06/13)
Substituted 6-phenyl-3(2H)-pyridazinone compounds are useful as cardiotonic agents. Said compounds cause a significant increase in myocardial contractility in the anesthetized dog. Said compounds are produced by reacting substituted γ-oxobenzenebutanoic acids with suitably substituted hydrazines to provide 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are dehydrogenated to the desired product. The intermediate 6-phenyl-4,5-dihydro-3(2H)-pyridazinones are themselves useful as cardiotonic agents.
Synthesis and Anxiolytic Activity of 6-(Substituted-phenyl)-1,2,4-triazolopyridazines
Albright, J. D.,Moran, D. B.,Wright, W. B.,Collins, J. B.,Beer, B.,et al.
, p. 592 - 600 (2007/10/02)
The synthesis of a series of 6-(substituted-phenyl)-1,2,4-triazolopyridazines (VIII) is reported.Some of these derivatives show activity in tests predictive of anxiolytic activity (a) protection against pentylenetetrazole-induced convulsions; (b)
6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents
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, (2008/06/13)
This disclosure describes novel substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines useful as hypotensive agents.
Agricultural fungicidal compositions containing 6-(substituted phenyl)-pyridazinones and said pyridazinones
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, (2008/06/13)
Agricultural fungicidal compositions containing as an active ingredient one or more of 6-(substitutedphenyl)-3(2H)-pyridazinone compounds, salts thereof and 6-(substituted-phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds, as well as new pyridazinone compo
