55901-95-6

Usage

Uses

Used in Pharmaceutical Industry:
6-(3,4-Dimethoxyphenyl)pyridazin-3-ol is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its presence in the molecular structure can modulate the biological activity, leading to the development of new drugs with improved efficacy and safety profiles.
Used in Organic Synthesis:
In the field of organic synthesis, 6-(3,4-Dimethoxyphenyl)pyridazin-3-ol serves as a valuable reactant for the preparation and N-alkylation of substituted pyridazones. Its reactivity allows for the creation of a diverse range of pyridazinone derivatives with potential applications in various industries.
Used in Chemical Research:
6-(3,4-Dimethoxyphenyl)pyridazin-3-ol is also utilized in chemical research as a model compound to study the effects of structural modifications on the properties and reactivity of pyridazinone-based compounds. This knowledge can be applied to design and develop novel molecules with specific functions and applications.

Upstream product

• 5333-34-6 3-(3,4-dimethoxybenzoyl)propionic acid 
• 39499-66-6 6-(3,4-dimethoxy-phenyl)-2,3,4,5-tetrahydropyridazin-3-one 

Relevant academic research and scientific papers

Copper-mediated rapid and facile oxidative dehydrogenation of dihydrobenzocarbazoles

Rapid method for the oxidative dehydrogenation of dihydrobenzocarbazoles has been introduced by using bench scale and commercially available reagent; copper chloride, in excellent yield with easy workup. The scope of the reaction has been studied with broad range of substitutes.

Iodine-mediated facile dehydrogenation of dihydropyridazin-3(2H)one

A new protocol for the dehydrogenation of dihydropyridazin-3(2H)-one has been carried out by catalytic amount of iodine in dimethyl sulphoxide in good yield with easy workup.

Endothelin receptor antagonists

This invention relates to pyridizinone derivatives of formula I STR1 wherein the various substituents are defined in the specification, and salts thereof, which have useful pharmacological properties, in particular endothelin receptor-antagonistic properties. The compounds are thus useful for the treatment of illnesses associated with endothelin activities, such as hypertension, cardiac insufficiency, coronary heart disease, renal, cerebral and myocardial ischaemia, renal insufficiency, cerebral infarct, subarachnoid haemorrhage, arteriosclerosis pulmonary high blood pressure, inflammations, asthma, prostate hyperplasia, endotoxic shock and in complications after the administration of immunosuppressants which produce renal vasoconstriction.

Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents

Substituted 6-phenyl-3(2H)-pyridazinone compounds are useful as cardiotonic agents. Said compounds cause a significant increase in myocardial contractility in the anesthetized dog. Said compounds are produced by reacting substituted γ-oxobenzenebutanoic acids with suitably substituted hydrazines to provide 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are dehydrogenated to the desired product. The intermediate 6-phenyl-4,5-dihydro-3(2H)-pyridazinones are themselves useful as cardiotonic agents.