55909-52-9Relevant academic research and scientific papers
Conformational analysis of 3-methyl-3-silathiane and 3-fluoro-3-methyl-3- silathiane
Kirpichenko, Svetlana V.,Kleinpeter, Erich,Ushakov, Igor A.,Shainyan, Bagrat A.
, p. 320 - 326 (2011)
The conformational equilibria of 3-methyl-3-silathiane 5, 3-fluoro-3-methyl-3-silathiane 6 and 1-fluoro-1-methyl-1-silacyclohexane 7 have been studied using low temperature 13C NMR spectroscopy and theoretical calculations. The conformer ratio
Ring Expansion to 6-, 7-, and 8-Membered Benzosilacycles through Strain-Release Silicon-Based Cross-Coupling
Han, Jie-Lian,Ju, Cheng-Wei,Qin, Ying,Zhao, Dongbing
, p. 8481 - 8485 (2020)
The synthesis of silacycles is highly appealing due to their important applications in organic synthesis, medicinal chemistry, and materials chemistry. However, sila-tetralins and sila-benzosuberanes are surprisingly under-represented due to a lack of general methods to access these compounds. We successfully developed a Pd-catalyzed strain-release silicon-based cross-coupling as an unprecedented ring-expansion method, which constitutes a general route for preparing diverse sila-tetralins and sila-benzosuberanes.
A Convenient Synthetic Route to Methylated Silacyclohexanes
Nguyen, Binh T.,Cartledge, Frank K.
, p. 2206 - 2210 (2007/10/02)
The von Braun degradation of substituted piperidines is a general and economical route to a variety of substituted primary and secondary α,ω-dibromopentanes.Grignard ring closure procedures have been carried out with seven different dibromopentanes in moderate to good yields.Ring closures with MeClSiCl2 lead to product mixtures which are appreciably enriched in one isomer, affording a convenient entry into a variety of derivatives which can be used for stereochemical studies.Assignment of structures based on 1H NMR and mass spectral fragmentation patterns is discussed
