55932-36-0Relevant academic research and scientific papers
Synthesis of 3,4-dihydro-2H-benzopyrans from phenols and α,β-unsaturated carbonyl compounds
Saimoto, Hiroyuki,Ogo, Yoshie,Komoto, Mie,Morimoto, Minoru,Shigemasa, Yoshihiro
, p. 2051 - 2054 (2007/10/03)
The reaction between 2′,4′-dihydroxyacetophenone and methyl vinyl ketone catalyzed by CaCl2/KOH in aqueous methanol yielded a 1,4-adduct, which was cyclized to 3,4-dihydro-2H-benzopyran (4) by acidic treatment. Analogous reaction using α, β-unsaturated aldehydes afforded benzopyrans (4) or (5) in a one-pot reaction. This method was successfully applied to the synthesis of β-tubaic acid (6), an antimicrobial 2H-1-benzopyran-6-carboxylic acid.
