55981-29-8

Basic information

• Product Name: 1,3,4-Thiadiazole, 2,5-dibroMo-
• Synonyms: 1,3,4-Thiadiazole, 2,5-dibroMo-;2,5-DibroMo-1,3,4-thiadiazole;2,5-DibroMothiadiazole
• CAS NO: 55981-29-8
• Molecular Formula: C₂Br₂N₂S
• Molecular Weight: 243.9078
• EINECS: -0
• Mol File: 55981-29-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 289.418 °C at 760 mmHg
• Flash Point: 128.836 °C
• Appearance: /
• Density: 2.496 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.77±0.10(Predicted)
• CAS DataBase Reference: 1,3,4-Thiadiazole, 2,5-dibroMo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4-Thiadiazole, 2,5-dibroMo-(55981-29-8)
• EPA Substance Registry System: 1,3,4-Thiadiazole, 2,5-dibroMo-(55981-29-8)

Safety Data

• Hazardous Substances Data: 55981-29-8(Hazardous Substances Data)

Usage

General Description

1,3,4-Thiadiazole, 2,5-dibromo- is a chemical compound with the formula C2H2Br2N2S. It is a heterocyclic compound containing a five-membered ring with two bromine atoms and a sulfur atom. 1,3,4-Thiadiazole, 2,5-dibromo- is primarily used in the field of medicinal chemistry and pharmaceutical research, where it has shown potential as a building block for the development of new drugs. It has been studied for its potential antifungal, antibacterial, and antiviral properties, making it a promising candidate for the development of new therapeutic agents. Additionally, it also has potential applications in the field of materials science and agrochemicals. However, further research is needed to fully understand and harness the potential of 1,3,4-Thiadiazole, 2,5-dibromo- in various fields.

Upstream product

• 37566-39-5 5-bromo-2-amino-1,3,4-thiadiazole 
• 4005-51-0 [1,3,4]Thiadiazol-2-ylamin 
• 2937-81-7 2,5-diamino-1,3,4-thiadiazole 

Downstream Products

• 3085-76-5 diisopropylcyanamide 
• 1352925-43-9 tert-butyl 4-(5-bromo-1,3,4-thiadiazol-2-yl)piperazine-1-carboxylate 
• 1026136-63-9 2-bromo-5-phenoxy-1,3,4-thiadiazole 
• 946884-40-8 2-bromo-5-(4-methoxyphenoxy)-1,3,4-thiadiazole 
• 170573-26-9 2-Bromo-5-(4-octyloxyphenyl)-1.3.4-thiadiazole 
• 53645-95-7 2-bromo-5-phenyl-1,3,4-thiadiazole 
• 21398-13-0 2,5-bis-phenylsulfanyl-[1,3,4]thiadiazole 

Relevant articles and documents

ASPARAGINE ENDOPEPTIDASE (AEP) INHIBITORS, COMPOSITIONS, AND USES RELATED THERETO

This disclosure relates to asparagine endopeptidase inhibitors and compositions and uses related thereto. In certain embodiments, the asparagine endopeptidase inhibitors are useful for improving memory, treating or preventing cancer, neurodegenerative diseases, and cognitive disorders. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising an asparagine endopeptidase inhibitor and a pharmaceutically acceptable excipient.

Discovery of a series of potent arylthiadiazole H3 antagonists

A series of 2-piperidinopiperidine-5-arylthiadiazoles was synthesized and subjected to a structure-activity relationship (SAR) investigation. The potency of this series was improved to the single digit nanomolar range. The key analogs were shown to be free of P450 issues, and they also maintained good ex vivo activity and brain penetration.

BIARYL SUBSTITUTED AZABICYCLIC ALKANE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY MODULATORS

The invention relates to biaryl substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.