3085-76-5Relevant articles and documents
1-Aza-3,4-diptiospholenes by [3 + 2] cycloaddition of 2-(diisopropylamino)phosphaethyne to diazo derivatives R1R2C=N2
Grobe, Joseph,Van Le, Duc,Immel, Franz,Krebs, Bernt,Laege, Mechtild
, p. 1271 - 1274 (1996)
The reaction of the (diisopropylamino)phosphaethyne (1) with diazo compounds of the type R1R2C=N2 (2a-2c) unexpectedly leads in high yields (60-90%) to the 1-aza-3,4-diphospholene derivatives 3a-3c, a new class of heterocycles. NMR investigations of the analogous reaction of 1 with diazocyclopentadiene 2d show that the multi-step formation of 3a-3c proceeds via the 1-aza-3,4-diphospholes 6a-6d as intermediates. VCH Verlagsgesellschaft mbH, 1996.
A allyl uncle amine compound by one-step synthesis method of cyano uncle amine compound (by machine translation)
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Paragraph 0070-0078, (2017/09/01)
The invention relates to a one-step synthesis of amine compound allyl unclecyano uncle amine compounds, which belongs to the technical field of organic synthetic method. The method specific synthetic process is as follows: in the airtight reaction environment, to the anhydrous organic solvent is added in the cyanogen bromide, under protection of inert gas, and then added dropwise to the solution in the allylic and high yield amine compound, to obtain allyl uncle amine compound concentration is 0.8 - 1 mol/L solution, at room temperature the reaction 16 - 24 hours later, after column chromatography separation and purification, to obtain a corresponding cyano uncle amine compound. The method to get rid of the expensive deallylation use of the catalyst, the synthesis step is less, raw materials are easy, cheap, mild reaction conditions, the operation is simple, easy to craft and industrialization. Yield 50% - 80% between. (by machine translation)
5,6,7,8-Tetrahydroquinolines. Part 7. Synthesis of 8-Cyano-5,6,7,8-tetrahydroquinolines; Di-isopropylcyanamide, a New Reagent for Cyanation of Organometallics
Crossley, Roger,Shepherd, Robin G.
, p. 2479 - 2482 (2007/10/02)
Di-isopropylcyanamide (1) is an effective reagent for the conversion of 8-lithio-5,6,7,8-tetrahydroquinolines into 8-cyano-5,6,7,8-tetrahydroquinolines. 8,8-Dicyano derivatives are not formed.A convenient synthesis of the reagent from disodium cyanamide is described.
