56005-11-9Relevant academic research and scientific papers
A new embelin from the mangrove Aegiceras corniculatum
Thota, Satya Prakasa Rao,Sarma, Nittala S.,Murthy,Kantamreddi,Wright
, p. 123 - 127 (2016/02/26)
One new compound (2) and five known compounds (1, 3-6) have been isolated from the mangrove plant Aegiceras corniculatum collected from the Godavari mangrove forest, India. The structure of the new compound has been established by 1H and 13C NMR spectroscopy and mass spectral data as 2,5-didehydroxy-6-methylembelin (2). The known compounds have been characterized as 4-hydroxy-2-methoxybenzamide (1), embelin (3), 5-O-ethylembelin (4), 5-O-methylembelin (5) and 4-methoxyresorcinol (6). Compounds 2-5 exhibit moderate antimalarial activity. Embelin (3) shows activity against chloroquine-resistant strains better than against chloroquine-sensitive strains of Plasmodium falciparum.
Hemisynthesis of selected embelin analogs and investigation of their proapoptotic activity against cancer cells
Viault, Guillaume,Babu, Katragadda Suresh,Gautier, Fabien,Barille-Nion, Sophie,Juin, Philippe,Tasseau, Olivier,Gree, Rene
, p. 1028 - 1034 (2014/01/06)
Embelin is a natural product, inhibitor of XIAP (X-chromosome-linked Inhibitor of APoptosis) with strong proapoptotic properties on cancer cells. In order to clarify the role of two OH groups on benzoquinone core, we have prepared by hemisynthesis close analogs of embelin, where these OH groups have been replaced in a systematic manner by OMe and OAc groups. Proapoptotic activities of six embelin derivatives have been studied as single agent, or in combination with TRAIL, and their abilities to interact with XIAP have been evaluated by Surface Plasmon Biacore. Our results show that these new embelin analogs have good proapoptotic properties against selected cancer cells, often higher than the natural product itself. Further, this activity is not directly mediated by XIAP. Altogether these preliminary results demonstrate that for active embelin analogs, the two OH groups are not absolutely required for anticancer activity, opening new possibilities for the design of proapoptotic derivatives in these series.
