56005-43-7Relevant academic research and scientific papers
2-METHYLENE-5-SUBSTITUTED METHYLENE CYCLOPENTANONE DERIVATIVES AND USE THEREOF
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Page/Page column 17, (2010/11/19)
The invention relates to 2-methylene-5-substituted-methylenecyclopentanone derivatives of formula I, and the use thereof. The derivatives of formula I as active components are useful for preparing a medicine for the treatment and/or prevention of cancer diseases such as breast cancer, lung cancer, colon cancer, rectal cancer, stomach cancer, prostate cancer, bladder cancer, uterus cancer, pancreatic cancer and ovary cancer. The active compounds of the invention may be used as an anticancer drug alone or used in combination with one or more other antitumor drugs. A combined therapy can be carried out by administrating each therapeutic component concurrently, subsequently or separately.
Synthesis and anticancer activity of 2-alkylaminomethyl-5-diaryl- methylenecyclopentanone hydrochlorides and related compounds
Wang, Jingli,Zhao, Linxiang,Wang, Rui,Lu, Min,Chen, Duo,Jing, Yongkui
, p. 1285 - 1291 (2007/10/03)
Eleven new diaryl-methylenecyclopentanone Mannich hydrochlorides and related compounds were synthesized with different modification on Mannich base and α,β-unsaturated bonds. The glutathione-binding ability, glutathione-s-transferase π (GSTπ) inhibition a
Palladium-catalyzed ring expansion reaction of 1-alkynylcyclobutanols with aryl iodides: An efficient route to 2-disubstituted methylenecyclopentanones
Wei, Li-Mei,Wei, Li-Lan,Pan, Wen-Bin,Wu, Ming-Jung
, p. 595 - 597 (2007/10/03)
The reaction of 1-alkynylcyclobutanols with aryl iodides in the presence of Pd(OAc)2 and Et3N in acetonitrile at 80°C for 24 h gives 2-disubstituted methylenecyclopentan-1-ones in modest to good yields. The tandem insertion-ring expansion process proceeds via the formation of an alkynyl π-complex, followed by migration of a carbon-carbon bond of the tert-alkanol to form the cyclopentanones stereoselectively.
