56006-48-5

Basic information

• Product Name: [R,(-)]-2-Ethylhexanoic acid
• Synonyms: [R,(-)]-2-Ethylhexanoic acid
• CAS NO: 56006-48-5
• Molecular Formula: C₈H₁₆O₂
• Molecular Weight: 144.21144
• Mol File: 56006-48-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 228 °C at 760 mmHg
• Flash Point: 116.6 °C
• Appearance: /
• Density: 0.926 g/cm³
• PKA: 4.82±0.25(Predicted)
• CAS DataBase Reference: [R,(-)]-2-Ethylhexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [R,(-)]-2-Ethylhexanoic acid(56006-48-5)
• EPA Substance Registry System: [R,(-)]-2-Ethylhexanoic acid(56006-48-5)

Safety Data

• Hazardous Substances Data: 56006-48-5(Hazardous Substances Data)

Usage

General Description

[R,(-)]-2-Ethylhexanoic acid, also known as 2-ethylhexanoic acid, is a saturated carboxylic acid with the chemical formula C8H16O2. It is a colorless, viscous liquid that is insoluble in water but soluble in organic solvents. This chemical is commonly used as a raw material in the production of metal carboxylates, which are used as catalysts in the manufacturing of polyurethanes and other polymers. Additionally, 2-ethylhexanoic acid is used as a chemical intermediate in the production of various products such as plasticizers, lubricants, and surfactants. It is also used in the synthesis of pharmaceuticals and agrochemicals. Despite its various uses, 2-ethylhexanoic acid can be harmful if ingested, inhaled, or absorbed through the skin, and precautions should be taken when handling this chemical.

Upstream product

• 149-57-5 2-Ethylhexanoic acid 

Downstream Products

• 760-67-8 2-ethylhexanoyl chloride 
• 4164-92-5 (-)(R)-heptane-carboxylic acid-(3)-amide 
• 2983-37-1 (-)-3-Ethoxycarbonyl-heptan 
• 2983-37-1 (-)(R)-heptane-carboxylic acid-⁽³⁾-ethyl ester 

Relevant articles and documents

Iterative saturation mutagenesis accelerates laboratory evolution of enzyme stereoselectivity: Rigorous comparison with traditional methods

Efficacy in laboratory evolution of enzymes is currently a pressing issue, making comparative studies of different methods and strategies mandatory. Recent reports indicate that iterative saturation mutagenesis (ISM) provides a means to accelerate directed evolution of stereoselectivity and thermostability, but statistically meaningful comparisons with other methods have not been documented to date. In the present study, the efficacy of ISM has been rigorously tested by applying it to the previously most systematically studied enzyme in directed evolution, the lipase from Pseudomonas aeruginosa as a catalyst in the stereoselective hydrolytic kinetic resolution of a chiral ester. Upon screening only 10 000 transformants, unprecedented enantioselectivity was achieved (E = 594). ISM proves to be considerably more efficient than all previous systematic efforts utilizing error-prone polymerase chain reaction at different mutation rates, saturation mutagenesis at hot spots, and/or DNA shuffling, pronounced positive epistatic effects being the underlying reason.