56008-40-3

Basic information

• Product Name: Benzenemethanamine, 2-iodo-N-(phenylmethyl)-
• CAS NO: 56008-40-3
• Molecular Formula: C14H14IN
• Molecular Weight: 323.176
• Mol File: 56008-40-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzenemethanamine, 2-iodo-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, 2-iodo-N-(phenylmethyl)-(56008-40-3)
• EPA Substance Registry System: Benzenemethanamine, 2-iodo-N-(phenylmethyl)-(56008-40-3)

Safety Data

• Hazardous Substances Data: 56008-40-3(Hazardous Substances Data)

Upstream product

• 40400-13-3 2-Iodobenzyl bromide 
• 100-46-9 benzylamine 
• 42365-45-7 (2-iodophenyl)methanamine hydrochloride 
• 100-52-7 benzaldehyde 
• 26260-02-6 2-iodobenzaldehyde 

Downstream Products

• 140420-21-9 2-[Benzyl-(2-iodo-benzyl)-amino]-1-cyclohexyl-ethanone 
• 1196708-76-5 (S)-5-benzyl-1,2,3,3a,5,6-hexahydrobenzo[f]pyrrolo-[1,2-a][1,4]diazepin-4-one 
• 1245604-39-0 t-butyl 2-[N-benzyl-N-(2-iodobenzyl)amino]acetate 

Relevant articles and documents

α-Oxocarboxylic Acids as Three-Carbon Insertion Units for Palladium-Catalyzed Decarboxylative Cascade Synthesis of Diverse Fused Heteropolycycles

A novel palladium-catalyzed decarboxylative cascade cyclization for the assembly of diverse fused heteropolycycles by employing α-oxocarboxylic acids as three-carbon insertion units is reported. This protocol enables the synthesis of isoquinolinedione- and indolo[2,1-a]isoquinolinone-fused benzocycloheptanones in moderate to good yields by the use of different aryl iodides, including alkene-tethered 2-iodobenzamides and 2-(2-iodophenyl)-1H-indoles. Notably, the approach achieves simultaneous construction of both six- and seven-membered rings via sequential intramolecular carbopalladation, C-H activation, and decarboxylation.

Palladium-Catalyzed Domino Heck/C-H Activation/Decarboxylation: A Rapid Entry to Fused Isoquinolinediones and Isoquinolinones

A new palladium-catalyzed tandem cyclization of various alkene-tethered aryl iodides has been presented. In this protocol, o-bromobenzoic acids are employed as coupling parters to achieve the insertion of aromatic rings by the cleavage of C(sp2)-Br and decarboxylation, thus assembling various dibenzoisoquinolinediones and dibenzoisoquinolinones. In addition, a seven-membered ring can be constructed by the use of 8-bromo-1-naphthoic acid. Notably, this approach enables regioselective product formation and features broad substrate scope.

Palladium-catalyzed double carbonylation-based diversity-oriented synthesis of 3,4-dihydroisoquinoline-1-carboxamides

Abstract A novel palladium-catalyzed double carbonylation approach toward the synthesis of 3,4-dihydroisoquinoline-1-carboxamides is reported. The method developed involves an initial palladium-catalyzed double carbonylation of an N-protected alkylamine a