560089-64-7Relevant academic research and scientific papers
Rh(I)-Catalyzed Hydroamidation of Olefins via Selective Activation of N-H Bonds in Aliphatic Amines
Dong, Kaiwu,Fang, Xianjie,Jackstell, Ralf,Laurenczy, Gabor,Li, Yuehui,Beller, Matthias
supporting information, p. 6053 - 6058 (2015/05/27)
Hydroamidation of olefins constitutes an ideal, atom-efficient method to prepare carboxylic amides from easily available olefins, CO, and amines. So far, aliphatic amines are not suitable for these transformations. Here, we present a ligand- and additive-free Rh(I) catalyst as solution to this problem. Various amides are obtained in good yields and excellent regioselectivities. Notably, chemoselective amidation of aliphatic amines takes place in the presence of aromatic amines and alcohols. Mechanistic studies reveal the presence of Rh-acyl species as crucial intermediates for the selectivity and rate-limiting step in the proposed Rh(I)-catalytic cycle. (Chemical Formula Presented).
Amide-forming ligation of acyltrifluoroborates and hydroxylamines in water
Dumas, Aaron M.,Molander, Gary A.,Bode, Jeffrey W.
supporting information; experimental part, p. 5683 - 5686 (2012/07/01)
Come together, right now: Acyltrifluoroborates and O-benzoyl hydroxylamines come together to form amides in water (see scheme). The ligations are complete within minutes at room temperature and do not require any reagents or catalysts. The reaction has a broad substrate scope and tolerates unprotected functional groups. Copyright
