56012-06-7

Usage

Uses

Used in Agricultural Applications:
2,4-Imidazolidinedione, 3-(4-chlorophenyl)is used as a soil conditioner for enhancing nitrogen use efficiency in crop production. It helps in reducing nitrogen leaching and ammonia emissions from agricultural fields, thereby improving the sustainability of farming practices.
Used in Water Treatment:
In the water treatment industry, 2,4-Imidazolidinedione, 3-(4-chlorophenyl)is employed as an antimicrobial agent to control the growth of microorganisms and maintain water quality.
Used in Industrial Applications:
2,4-Imidazolidinedione, 3-(4-chlorophenyl)is used as a stabilizer for chlorine disinfectants in various industries, ensuring the effectiveness of these disinfectants over time.
However, it is important to consider the potential environmental and health impacts of DCD, such as its contribution to greenhouse gas emissions and the presence of residues in food products. Further research and responsible use are necessary to mitigate these concerns.

Upstream product

• 7141-70-0 5-(4-chloro-phenyl)-hydantoic acid ethyl ester 
• 104-12-1 p-chlorphenylisocyanate 
• 56-40-6 glycine 
• 106-47-8 4-chloro-aniline 
• 2949-22-6 Glycine ethyl ester isocyanate 
• 590-28-3 potassium cyanate 
• 3289-75-6 2-chloro-N-(4-chlorophenyl)acetamide 

Downstream Products

• 1174133-47-1 1-[2-(4-chlorophenoxy)propanoyl]-3-(4-chlorophenyl)imidazolidine-2,4-dione 
• 1174133-44-8 3-(4-chlorophenyl)-1-[2-(2,4-dichlorophenoxy)propanoyl]imidazolidine-2,4-dione 
• 1174133-50-6 3-(4-chlorophenyl)-1-[2-(4-fluorophenoxy)propanoyl]imidazolidine-2,4-dione 
• 1174133-41-5 3-(4-chlorophenyl)-1-(2-phenoxypropanoyl)imidazolidine-2,4-dione 
• 56012-25-0 3-(4-chloro-phenyl)-1-(dichloro-fluoro-methylsulfanyl)-imidazolidine-2,4-dione 
• 1387637-37-7 C₁₂H₁₂ClN₃O₂ 
• 1388265-69-7 C₃₃H₃₁ClFN₉O₄S 

Relevant academic research and scientific papers

Structural optimization of non-nucleoside DNA methyltransferase inhibitor as anti-cancer agent

Inhibition of DNA methyltransferase 1 (DNMT1) can reverse the malignant behavior of cancer cells by restoring expression of aberrantly silenced genes that are required for differentiation, senescence, and apoptosis. Clinically used DNMT1 inhibitors decitabine and azacitidine inhibit their target by covalent trapping after incorporation into DNA as azacytidine analogs. These nucleoside compounds are prone to rapid enzymatic inactivation in blood, posing challenges to the development of purely epigenetic dosing schedules. Non-nucleoside compounds that suppress expression or function of DNMT1 may overcome this problem. Using a high-throughput PCR-based site specific chromatin condensation assay, we identified a compound that reactivated Cyclin-Dependent Kinase Inhibitor 2A (CDKN2A) in myeloma cells and suppressed expression of DNMT1 from a library of 5120 chemically diverse small molecules. Lead optimization was performed to generate 26 new analogs with lung cancer proliferation and DNMT1 expression as activity readout. Two of the new derivatives showed 2 fold improvement of growth inhibiting potency and also decreased DNMT1 protein levels in lung cancer cells.

Synthesis and herbicidal activity of 3-aryl-1-[2-(aryloxy)propanoyl] imidazolidine-2,4-diones

(Chemical Equation Presented) A series of novel 3-aryl-1-[2-(aryloxy) propanoyl]imidazolidine-2,4-diones were synthesized by the condensation of 3-aryl-imidazolidine-2,4-diones with 2-(aryloxy)propanoyl chlorides under mild conditions. Their structures we

SUBSTITUENT EFFECTS ON HYDROLYTIC STABILITY AND HERBICIDAL ACTIVITY OF 3-ARYLIMIDAZOLIDINE-2,4-DIONES

Twenty-one derivatives of imidazolidine-2,4-dione have been prepared by reactions of substituted amino acids with aryl isocyanates in aqueous medium.Pre- and post-emergent herbicidal activities of all the compounds have been tested, and stability of five derivatives has been followed in aqueous medium within the pH range from 7.6 to 13.0.The highest pre-emergent herbicidal activity has been found with the derivatives XI-XVI which inhibit the growth of most indicator plants at the doses of 1.6 kg/ha.The derivatives studied are relatively stable in aqueous medium, the hydrolysis half-life of the compound XI being 9 days at pH 8.