560134-60-3Relevant academic research and scientific papers
Synthesis of Tetrahydroisoquinolines through an Iron-Catalyzed Cascade: Tandem Alcohol Substitution and Hydroamination
Marcyk, Paul T.,Cook, Silas P.
, p. 6741 - 6744 (2019/09/07)
Rapid assembly of saturated nitrogen heterocycles - the synthetically more challenging variants of their aromatic relatives - can expedite the synthesis of biologically relevant molecules. Starting from a benzylic alcohol tethered to an unactivated alkene, an iron-catalyzed tandem alcohol substitution and hydroamination provides access to tetrahydroisoquinolines in a single synthetic step. Using a mild iron-based catalyst, the combination of these operations forms two carbon-nitrogen bonds and provides a unique annulation strategy to access this valuable core.
Cyclization of aryl acyl radicals generated from S-(4-cyano)phenyl thiolesters by a nickel complex catalyzed electroreduction
Ozaki, Shigeko,Adachi, Masashi,Sekiya, Sayaka,Kamikawa, Rie
, p. 4586 - 4589 (2007/10/03)
Aromatic acyl radicals generated from S-(4-cyano)phenyl 2-alkenylthiobenzoate by a nickel complex catalyzed electroreduction undergo 5- and 6-exo cyclization to give 1-indanone and dihydro-1-naphthalenone derivatives, respectively.
Intramolecular addition reactions of functionalized arylcarbenes to double bonds
Kirmse, Wolfgang,H?mberger, Günter
, p. 3925 - 3934 (2007/10/02)
Arylcarbenes with unsaturated ortho substituents (vinyloxy, 1-propenyloxy, allyl, 2-butenyl, 2,4-pentadienyl) were generated in methanol by photolysis of diazo precursors. Intermolecular OH insertion was found to compete with intramolecular addition to th
