56018-53-2

Usage

Uses

Used in Organic Synthesis:
2-(4-methoxyphenyl)-1,3-diphenylimidazolidine is used as a building block for the synthesis of biologically active compounds. Its unique structure allows for the creation of complex molecules that can be utilized in a wide range of applications, from pharmaceuticals to agrochemicals.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-(4-methoxyphenyl)-1,3-diphenylimidazolidine is used as a chiral ligand in catalysis. Its ability to influence the stereochemistry of reactions makes it a valuable tool in the development of enantiomerically pure drugs, which are essential for ensuring the desired therapeutic effects and minimizing potential side effects.
Used in Catalyst Development:
2-(4-methoxyphenyl)-1,3-diphenylimidazolidine is also used in the development of catalysts for asymmetric synthesis. Its chiral nature can be exploited to create catalysts that selectively produce one enantiomer of a compound over another, which is crucial in the production of pharmaceuticals and other chiral molecules where the stereochemistry can significantly impact the activity and safety of the final product.

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 150-61-8 N,N'-diphenylethylenediamine 
• 62-53-3 aniline 

Relevant academic research and scientific papers

Synthesis and evaluation of antiinflammatory and analgesic activity of some new 1,3-diphenyl-2-aryltetrahydroimidazoles

In an effort to search for new antiinflammatory and analgesic agents, some new tetrahydroimidazole derivatives 2a-2g have been synthesized via condensation of 1,2-dianilinoethane with various aldehydes. Characterization of the newly synthesized compounds has been done on the basis of 1H NMR and mass spectral data. The resulting compounds have been evaluated for their antiinflammatory activity. The activity of compounds 2b and 2c is excellent and comparable to indomethacin. All these compounds have been tested for their analgesic activity also and their LD50 determined. Compounds 2b and 2c show a comparable activity with aspirin. The MTD for all the compounds is found to be >1800 mg/kg.

2,3-Dichloro-5,6-dicyano-1,4-benzoquinone, a Mild Catalyst for the Formation of Carbon-Nitrogen Bonds

2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) catalyzes the preparation of N-tetrahydropyranylbenzazoles, 2-substituted 1,3-diphenylimidazolidines, and N-(arylmethylene)benzene-1,2-diamines.In the latter case, use of one equivalent of DDQ provides a novel one-pot method for the synthesis of 1H-benzimidazoles.

BENTONITE K10 CLAY, AN EFFICIENT CATALYST FOR THE FORMATION OF NITROGEN DERIVATIVES

Bentonite K10 clay has been used to catalyze the formation of enamino carbonyl derivatives, 2-methyl-1H-benzimidazoles, Hantzsch 1,4-dihydropyridines, Hantzsch pyridines, 2-substituted 1,3-diphenylimidazolidines, and tetrahydropyranylbenzazoles.

NOVEL SYNTHESES OF HETEROCYCLES WITH N-(1-HALOALKYL)AZINIUM HALIDES PART 1. PREPARATION OF IMIDAZOLIDINES

N-(1-Chloroalkyl)pyridinium chlorides, prepared from thionyl chloride, pyridine, and an aldehyde, readily react with N,N'-disubstituted 1,2-ethanediamine to yield imidazolidines under mild and neutral conditions.