56020-69-0

Upstream product

• 526195-40-4 (9R)-methyl-1,4,8-trioxaspiro[4.9]tetradecan-7-one 
• 71203-69-5 methyl 3-oxooctyl-7-enoate 
• 526195-36-8 (2-pent-4-enyl[1,3]dioxolan-2-yl)acetic acid (1'R)-methylprop-2-ynyl ester 
• 526195-38-0 (2-pent-4-enyl[1,3]dioxolan-2-yl)acetic acid (1'R)-methylallyl ester 
• 211927-46-7 (2-pent-4-enyl[1,3]dioxolan-2-yl)acetic acid 
• 145091-04-9 (2-pent-4-enyl[1,3]dioxolan-2-yl)acetic acid methyl ester 

Relevant academic research and scientific papers

A ring-closing metathesis approach toward formal total synthesis of (+)-diplodialide A

An asymmetric formal total synthesis of diplodialide A la has been achieved starting from methyl acetoacetate 6 and (R)-3-buten-2-ol 7. The macrocyclic ring core of (+)-diplodialide A 1a was constructed, in an excellent yield, by using a ring-closing metathesis strategy.