56021-79-5

Upstream product

• 123-75-1 pyrrolidine 
• 89-82-7 pulegone 
• 23733-71-3 (R)-(+)-pulegone semicarbazone 

Downstream Products

• 139943-22-9 (3R)-2-(2-Cyanoethyl)-6-isopropylidene-3-methylcyclohexanone 

Relevant academic research and scientific papers

Ruthenium-Catalyzed Hydration of Nitriles and Transformation of δ-Ketonitriles to Ene-lactams: Total Synthesis of (-)-Pumiliotoxin C

Hydration of nitriles with 1-2 equivalents of water can be performed efficiently by using RuH2(PPh3)4 catalyst to give the corresponding amides.Under the similar reaction conditions, δ-ketonitriles can be converted into the corresponding ene-lactams, which are versatile synthetic intermediates.The efficiency of the reaction is demonstrated by the short-step synthesis of (-)-pumiliotoxin C.