56044-12-3

Basic information

• Product Name: 2,4-DIOXO-1,2,3,4-TETRAHYDRO-QUINAZOLINE-6-SULFONYL CHLORIDE
• Synonyms: 2,4-DIOXO-1,2,3,4-TETRAHYDRO-QUINAZOLINE-6-SULFONYL CHLORIDE;ASINEX-REAG BAS 12411409;TIMTEC-BB SBB012062;2,4-Dioxo-1,2,3,4-tetrahydro-6-quinazolinesulfonyl chloride
• CAS NO: 56044-12-3
• Molecular Formula: C₈H₅ClN₂O₄S
• Molecular Weight: 260.65
• EINECS: 946-697-3
• Mol File: 56044-12-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 307-309 °C(Solv: heptane (142-82-5))
• Appearance: /
• Density: 1.649±0.06 g/cm3(Predicted)
• PKA: 8.91±0.20(Predicted)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 2,4-DIOXO-1,2,3,4-TETRAHYDRO-QUINAZOLINE-6-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIOXO-1,2,3,4-TETRAHYDRO-QUINAZOLINE-6-SULFONYL CHLORIDE(56044-12-3)
• EPA Substance Registry System: 2,4-DIOXO-1,2,3,4-TETRAHYDRO-QUINAZOLINE-6-SULFONYL CHLORIDE(56044-12-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: 8
• Hazardous Substances Data: 56044-12-3(Hazardous Substances Data)

Usage

Description

2,4-DIOXO-1,2,3,4-TETRAHYDRO-QUINAZOLINE-6-SULFONYL CHLORIDE is an organic compound with the chemical formula C?H?ClN?O?S. It is a derivative of quinazoline, a fused bicyclic compound consisting of a pyrimidine and a benzene ring. 2,4-DIOXO-1,2,3,4-TETRAHYDRO-QUINAZOLINE-6-SULFONYL CHLORIDE is characterized by its sulfonyl chloride functional group, which makes it a versatile reagent in organic synthesis.

Uses

Used in Pharmaceutical Industry:
2,4-DIOXO-1,2,3,4-TETRAHYDRO-QUINAZOLINE-6-SULFONYL CHLORIDE is used as a reactant for the preparation of prostaglandin agonists. Prostaglandins are a group of lipid compounds that have various physiological effects, including the regulation of blood flow, inflammation, and pain. They are essential in the treatment of various conditions, such as bone disorders.
In the pharmaceutical industry, 2,4-DIOXO-1,2,3,4-TETRAHYDRO-QUINAZOLINE-6-SULFONYL CHLORIDE plays a crucial role in the synthesis of prostaglandin agonists, which are used to treat bone disorders. These agonists help in the regulation of bone metabolism, promoting bone formation and preventing bone loss, thus providing relief and improving the quality of life for patients suffering from such conditions.

Upstream product

• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 

Downstream Products

• 1332356-03-2 N-((2S,3R)-1-(2-(2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl-sulfonyl)hydrazinyl)-3-hydroxy-1-oxobutan-2-yl)benzenesulfonamide 
• 1214468-35-5 2,4-dioxo-N-[4-(pyridin-3-yloxy)phenyl]-1,2,3,4-tetrahydroquinazoline-6-sulfonamide 

Relevant articles and documents

Quinazolines 1. Synthesis and chemical reactions of 6-chlorosulfonyl- quinazoline-2,4-diones

Treatment of quinazoline-2,4-dione and its symmetrical 1,3-dialkyl derivatives with chlorosulfonic acid gave the corresponding 6- chlorosulfonylquinazoline-2,4-diones. Reaction of the compounds obtained with nucleophilic agents (water, ammonia, aliphatic and cyclic amines) gave the corresponding free 2,4-dioxoquinazoline-6-sulfonic acids, 6- sulfamidoquinazoline-2,4-diones, and 2,4-dioxoquinazoline-6-sulfonic acid amides.

2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG

The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.