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56044-12-3

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56044-12-3 Usage

Uses

2,4-Dioxo-1,2,3,4-tetrahydro-quinazoline-6-sulfonyl chloride is used as a reactant in the preparation prostaglandin agonists and their use to treat bone disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 56044-12-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,0,4 and 4 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 56044-12:
(7*5)+(6*6)+(5*0)+(4*4)+(3*4)+(2*1)+(1*2)=103
103 % 10 = 3
So 56044-12-3 is a valid CAS Registry Number.

56044-12-3 Well-known Company Product Price

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  • Alfa Aesar

  • (H54833)  2,4-Dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonyl chloride, 97%   

  • 56044-12-3

  • 250mg

  • 871.0CNY

  • Detail
  • Alfa Aesar

  • (H54833)  2,4-Dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonyl chloride, 97%   

  • 56044-12-3

  • 1g

  • 2616.0CNY

  • Detail
  • Alfa Aesar

  • (H54833)  2,4-Dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonyl chloride, 97%   

  • 56044-12-3

  • 5g

  • 10426.0CNY

  • Detail

56044-12-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,4-Dioxo-1,2,3,4-tetrahydro-quinazoline-6-sulfonyl chloride

1.2 Other means of identification

Product number -
Other names 2,4-dioxo-1H-quinazoline-6-sulfonyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:56044-12-3 SDS

56044-12-3Relevant articles and documents

Quinazolines 1. Synthesis and chemical reactions of 6-chlorosulfonyl- quinazoline-2,4-diones

Kuryazov,Mukhamedov,Shakhidoyatov

, p. 324 - 329 (2008)

Treatment of quinazoline-2,4-dione and its symmetrical 1,3-dialkyl derivatives with chlorosulfonic acid gave the corresponding 6- chlorosulfonylquinazoline-2,4-diones. Reaction of the compounds obtained with nucleophilic agents (water, ammonia, aliphatic and cyclic amines) gave the corresponding free 2,4-dioxoquinazoline-6-sulfonic acids, 6- sulfamidoquinazoline-2,4-diones, and 2,4-dioxoquinazoline-6-sulfonic acid amides.

2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG

-

Paragraph 00192; 00193; 00194, (2016/07/05)

The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.

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