56045-73-9

Basic information

• Product Name: AIdUrd
• Synonyms: AIdUrd;5'-amido-2',5'-dideoxy-5-iodouridine
• CAS NO: 56045-73-9
• Molecular Formula: C₉H₁₂IN₃O₄
• Molecular Weight: 353.11375
• Mol File: 56045-73-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AIdUrd(CAS DataBase Reference)
• NIST Chemistry Reference: AIdUrd(56045-73-9)
• EPA Substance Registry System: AIdUrd(56045-73-9)

Safety Data

• Hazardous Substances Data: 56045-73-9(Hazardous Substances Data)

Upstream product

• 54-42-2 5-Iodo-2'-deoxyuridine 
• 58349-27-2 2'-deoxy-5-iodo-5'-O-(p-toluenesulfonyl)uridine 
• 27999-47-9 ((2R,3S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl 4-methylbenzenesulfonate 
• 35959-37-6 5’-azido-2’,5’-dideoxyuridine 
• 58349-30-7 5-Iodo-5'-azido-2',5'-dideoxyuridine 
• 35959-38-7 5'-Amino-2',5'-dideoxy-uridine 

Downstream Products

• 119423-53-9 5'-[2-(2,6-dichlorophenyl)acetamido]-2',5'-dideoxy-5-iodouridine 

Relevant articles and documents

Norepinephrine-Transporter-Targeted and DNA-Co-Targeted Theranostic Guanidines

High risk neuroblastoma often recurs, even with aggressive treatments. Clinical evidence suggests that proliferative activities are predictive of poor outcomes. This report describes syntheses, characterization, and biological properties of theranostic guanidines that target norepinephrine transporter and undergo intracellular processing, and subsequently their catabolites are efficiently incorporated into DNA of proliferating neuroblastoma cells. Radioactive guanidines are synthesized from 5-radioiodo-2′-deoxyuridine, a molecular radiotherapy platform with clinically proven minimal toxicities and DNA-targeting properties. The transport of radioactive guanidines into neuroblastoma cells is active as indicated by the competitive suppression of cellular uptake by meta-iodobenzylguanidine. The rate of intracellular processing and DNA uptake is influenced by the agent's catabolic stability and cell population doubling times. The radiotoxicity is directly proportional to DNA uptake and duration of exposure. Biodistribution of 5-[125I]iodo-3′-O-(?-guanidinohexanoyl)-2′-deoxyuridine in a mouse neuroblastoma model shows significant tumor retention of radioactivity. Neuroblastoma xenografts regress in response to the clinically achievable doses of this agent.

Synthesis of Analogues of 5-Iodo-2'-deoxyuridine-5'-diphosphate

The synthesis of three types of diphosphate analogues of 5-iodo-2'-deoxyuridine-5'-diphosphate is reported.Routes are described to the 5'-phosphonoacetamido, the 5'-N-phosphonosulfamoyl and the 5'-O-sulfamoylcarbamoyl derivatives, 2, 3 and 4 starting from

Anti herpes simplex viral compounds and their synthesis

The compounds 5'-amino-2',5'-dideoxy-5-iodouridine; 5'-amino-2',5'-dideoxy-5-bromouridine; and the pharmaceutically acceptable acid addition salts thereof have been found to be potent inhibitors of herpes simplex virus.