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56046-15-2 Usage

General Description

[S,(-)]-7-Hydroxy-3,7-dimethyloctanoic acid is a chemical compound with a molecular formula of C10H20O3. It is a chiral compound, meaning it has a non-superimposable mirror image, and the S-enantiomer is the active form. [S,(-)]-7-Hydroxy-3,7-dimethyloctanoic acid is often found in nature and is a major component of the pheromones of several insect species. It also has potential pharmaceutical applications, particularly in the area of anti-inflammatory drugs. Additionally, it is used as a precursor for the synthesis of various organic compounds. Studies have shown that this compound has anti-inflammatory and anti-oxidant properties, making it potentially useful for a variety of medical applications.

Check Digit Verification of cas no

The CAS Registry Mumber 56046-15-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,0,4 and 6 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 56046-15:
112 % 10 = 2
So 56046-15-2 is a valid CAS Registry Number.

56046-15-2Downstream Products

56046-15-2Relevant articles and documents

The Odorant (R)-Citronellal Attenuates Caffeine Bitterness by Inhibiting the Bitter Receptors TAS2R43 and TAS2R46

Suess, Barbara,Brockhoff, Anne,Meyerhof, Wolfgang,Hofmann, Thomas

, p. 2301 - 2311 (2018/03/21)

Sensory studies showed the volatile fraction of lemon grass and its main constituent, the odor-active citronellal, to significantly decrease the perceived bitterness of a black tea infusion as well as caffeine solutions. Seven citronellal-related derivatives were synthesized and shown to inhibit the perceived bitterness of caffeine in a structure-dependent manner. The aldehyde function at carbon 1, the (R)-configuration of the methyl-branched carbon 3, and a hydrophobic carbon chain were found to favor the bitter inhibitory activity of citronellal; for example, even low concentrations of 25 ppm were observed to reduce bitterness perception of caffeine solution (6 mmol/L) by 32%, whereas (R)-citronellic acid (100 pm) showed a reduction of only 21% and (R)-citronellol (100 pm) was completely inactive. Cell-based functional experiments, conducted with the human bitter taste receptors TAS2R7, TAS2R10, TAS2R14, TAS2R43, and TAS2R46 reported to be sensitive to caffeine, revealed (R)-citronellal to completely block caffeine-induced calcium signals in TAS2R43-expressing cells, and, to a lesser extent, in TAS2R46-expressing cells. Stimulation of TAS2R43-expressing cells with structurally different bitter agonists identified (R)-citronellal as a general allosteric inhibitor of TAS2R43. Further structure/activity studies indicated 3-methyl-branched aliphatic aldehydes with a carbon chain of ≥4 C atoms as best TAS2R43 antagonists. Whereas odor-taste interactions have been mainly interpreted in the literature to be caused by a central neuronal integration of odors and tastes, rather than by peripheral events at the level of reception, the findings of this study open up a new dimension regarding the interaction of the two chemical senses.

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