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18951-85-4

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18951-85-4 Usage

Description

(R)-(+)-Citronellic Acid, an oxidized derivative of Citronellal, is a monoterpene compound that originates from the metabolic processes of plants. It exists as a colorless liquid and holds potential applications across various industries due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
(R)-(+)-Citronellic Acid is used as an intermediate in the synthesis of various pharmaceutical compounds for its ability to contribute to the development of novel drugs with potential therapeutic benefits.
Used in Fragrance Industry:
(R)-(+)-Citronellic Acid is used as a key ingredient in the creation of fragrances for its distinct scent properties, enhancing the overall aroma of perfumes, colognes, and other scented products.
Used in Cosmetic Industry:
(R)-(+)-Citronellic Acid is utilized as a component in the formulation of cosmetics for its potential benefits to skin care, such as moisturizing and soothing properties, contributing to the effectiveness of skincare products.
Used in Flavor Industry:
(R)-(+)-Citronellic Acid is employed as a flavoring agent in the food and beverage industry, adding a unique taste to various products, thanks to its characteristic flavor profile.
Used in Agrochemical Industry:
(R)-(+)-Citronellic Acid is used as a component in the development of agrochemicals, such as pesticides and insecticides, leveraging its properties to control and manage pests in agriculture.

Check Digit Verification of cas no

The CAS Registry Mumber 18951-85-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,9,5 and 1 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 18951-85:
(7*1)+(6*8)+(5*9)+(4*5)+(3*1)+(2*8)+(1*5)=144
144 % 10 = 4
So 18951-85-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H18O2/c1-8(2)5-4-6-9(3)7-10(11)12/h5,9H,4,6-7H2,1-3H3,(H,11,12)/t9-/m1/s1

18951-85-4 Well-known Company Product Price

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  • Aldrich

  • (340499)  (R)-(+)-Citronellicacid  98%

  • 18951-85-4

  • 340499-5G

  • 1,774.89CNY

  • Detail

18951-85-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (3R)-3,7-dimethyloct-6-enoic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18951-85-4 SDS

18951-85-4Relevant articles and documents

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Overberger,C.G.,Weise,J.K.

, p. 3525 - 3532 (1968)

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Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD)

Lagu, Bharat,Kluge, Arthur F.,Tozzo, Effie,Fredenburg, Ross,Bell, Eric L.,Goddeeris, Matthew M.,Dwyer, Peter,Basinski, Andrew,Senaiar, Ramesh S.,Jaleel, Mahaboobi,Tiwari, Nirbhay Kumar,Panigrahi, Sunil K.,Krishnamurthy, Narasimha Rao,Takahashi, Taisuke,Patane, Michael A.

, p. 935 - 940 (2018)

The X-ray structure of the previously reported PPARδ modulator 1 bound to the ligand binding domain (LBD) revealed that the amide moiety in 1 exists in the thermodynamically disfavored cis-amide orientation. Isosteric replacement of the cis-amide with five-membered heterocycles led to the identification of imidazole 17 (MA-0204), a potent, selective PPARδ modulator with good pharmacokinetic properties. MA-0204 was tested in vivo in mice and in vitro in patient-derived muscle myoblasts (from Duchenne Muscular Dystrophy (DMD) patients); 17 altered the expression of PPARδ target genes and improved fatty acid oxidation, which supports the therapeutic hypothesis for the study of MA-0204 in DMD patients.

Syntheses of optically active citronellol, citronellal, and citronellic acid by microbial oxidation and double coupling system in an interface bioreactor

Oda, Shinobu,Sugai, Takeshi,Ohta, Hiromichi

, p. 2819 - 2823 (2000)

We have already reported that (RS)-Citronellol [(RS)-1] can be optically resolved via a transacetylation with acetyl coenzyme A [acetyl-CoA] by the aid of alcohol acetyltransferase [AATFase] in Pichia kluyveri IFO 1165, which we have referred to as a double coupling system (E value, 30 to 40). In this system, although (R)-1 is obtained at over 98% ee, (S)-Citronellyl acetate [(S)-2] is prepared at 70 to 80% ee. In this article, we report on the conversion of (R)-1 to (R)-Citronellal [(R)-3] and (R)-Citronellic acid [(R)-4] in high yield without racemization by the aid of Rhodococcus equi JCM 6817 and Geotrichum candidum JCM 01747, respectively. On the other hand, the low ee of (S)-1 (78% ee) prepared via the alkaline hydrolysis of (S)-2 is converted to optically active (S)-1 and (S)-4 in high yield with a repeated double coupling system with P. kluyveri IFO 1165 and via enantioselective oxidation with Candida viswanathii IFO 10321, respectively. Thus, five optically active terpenoids related to citronellol, except for (S)-3, were efficiently synthesized via microbial transformations in an interface bioreactor.

Enantioselective oxidation of racemic citronellol with an interface bioreactor

Oda, Shinobu,Kato, Akio,Matsudomi, Naotoshi,Ohta, Hiromichi

, p. 83 - 87 (1996)

Microbial oxidation of racemic citronellol was done on the interface between a nutrient agar plate and decane (interface bioreactor). While Rhodococcus accumulated (R)-citronellal (21-80% e.e.), many yeasts accumulated (S)-citronellic acid (20-68% e.e.) as the oxidation product. For the production of (R)-citronellal and (S)-citronellic acid, Rhodococcus equi IFO 3730 and Hansenula anomala IFO 0147 were the best strains, respectively. While citronellol-oxidation in R. equi IFO 3730 was (S)-selective, citronellal-oxidation was (R)-selective. Although H. anomala had also both (S)-selective alcohol and aldehyde dehydrogenases (constitutive, NAD+-dependent), the equilibrium of the alcohol dehydrogenase shifted to reduction of citronellal. Geotrichum candidum JCM 01747 accumulated very high concentrations of citronellic acid (conversion yield 90% in 5 days or accumulation 65 mg/ml in 13 days) in spite of the strong toxicity of the acid, although the optical purity was low. For the alleviation of the toxicity of citronellol and accumulation of toxic citronellic acid, the interface bioreactor is superior to the organic-aqueous two-liquid-phase system (dispersion system).

Macrocyclic compounds as EGFR inhibitors and uses thereof

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Paragraph 0095; 0100-0102, (2021/10/27)

The invention belongs to the field of pharmaceutical chemistry and relates to a macrocyclic compound serving as EGFR inhibitor and application thereof, in particular to a compound shown in the formula (I) or an isomer thereof. Pharmaceutically acceptable salts, solvates, crystalline or prodrugs, processes for their preparation and include pharmaceutical compositions of these compounds and the use of these compounds or compositions for the treatment EGFR-mediated diseases.

MACROCYCLIC COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS

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Page/Page column 453; 531; 532, (2020/03/29)

Compounds, methods of use, and processes for making inhibitors of complement factor D or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade. The inhibitors of factor D described herein reduce excessive activation of complement.

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