56046-36-7 Usage
Description
8-Bromohypoxanthine is a halogenated purine analog belonging to the purine family and is a derivative of hypoxanthine. It features a bromine substituent at the 8 position and is commonly utilized as a biochemical tool for studying purine metabolism and as a research reagent in biochemistry.
Uses
Used in Biochemical Research:
8-Bromohypoxanthine is used as a biochemical tool for investigating purine metabolism due to its structural similarity to naturally occurring purines, allowing researchers to probe the mechanisms and pathways involved in these processes.
Used in Drug Development:
8-Bromohypoxanthine is used as a research reagent in the field of biochemistry, aiding in the development of new drugs and therapeutic agents. Its potential therapeutic properties, such as anti-inflammatory and anti-cancer activities, make it a valuable compound for exploring novel treatment options.
Used in Immunology Research:
8-Bromohypoxanthine is used as a research compound in immunology to study its role in modulating immune responses. Understanding its effects on the immune system can contribute to the development of immunomodulatory therapies and interventions.
Used in Disease Target Identification:
8-Bromohypoxanthine is used as a potential drug target for various diseases, as it has been studied for its possible impact on disease progression and management. Identifying its role in disease pathways can lead to the discovery of new therapeutic strategies and treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 56046-36-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,0,4 and 6 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 56046-36:
(7*5)+(6*6)+(5*0)+(4*4)+(3*6)+(2*3)+(1*6)=117
117 % 10 = 7
So 56046-36-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H3BrN4O/c6-5-9-2-3(10-5)7-1-8-4(2)11/h1-2H,(H,7,8,9,10,11)
56046-36-7Relevant articles and documents
Chemical radiation studies of 8-bromo-2′ -deoxyinosine and 8-bromoinosine in aqueous solutions
Russo, Marialuisa,Jimenez, Liliana B.,Mulazzani, Quinto G.,D'Angelantonio, Mila,Guerra, Maurizio,Miranda, Miguel A.,Chatgilialoglu, Chryssostomos
, p. 7684 - 7693 (2007/10/03)
The reactions of hydrated electrons (eaq-) with 8-bromo-2′-deoxyinosine (8) and 8-bromoinosine (12) have been investigated by radiolytic methods coupled with product studies and have been addressed computationally by means of BB1K-HMDFT calculations. Pulse radiolysis revealed that one-electron reductive cleavage of the C-Br bond gives the C8 radical 9 or 13 followed by a fast radical translocation to the sugar moiety. Selective generation of a C5′ radical occurs in the 2′-de-oxyribo derivative, whereas in the ribo analogue the reaction is partitioned between the C5′ and C2′ positions with similar rates. Both C5′ radicals undergo cyclizations, 10→11 and 14→15, with rate constants of 1.4 × 105 and of 1.3 × 104 s-1, respectively. The redox properties of radicals 10 and 11 have also been investigated. A synthetically useful photoreaction has also been developed as a one-pot procedure that allows the conversion of 8 to 5′,8-cyclo-2′- deoxyinosine in a high yield and a diastereoisomeric ratio (5′R)/ (5′S) of 4:1. The present results are compared with data previously obtained for 8-bromoadenine and 8-bromoguanine nucleosides. Theory suggests that the behavior of 8-bromopurine derivatives with respect to solvated electrons can be attributed to differences in the energy gap between the π*- and σ*-radical anions.
