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56046-36-7

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56046-36-7 Usage

General Description

8-Bromohypoxanthine is a chemical compound that belongs to the purine family and is a derivative of hypoxanthine. It is a halogenated purine analog with a bromine substituent at the 8 position. 8-Bromohypoxanthine is often used as a biochemical tool to study purine metabolism and as a research reagent in the field of biochemistry. It has been investigated for its potential therapeutic properties, including its anti-inflammatory and anti-cancer activities. Additionally, 8-Bromohypoxanthine has been studied for its role in modulating immune responses and as a potential drug target for various diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 56046-36-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,0,4 and 6 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 56046-36:
(7*5)+(6*6)+(5*0)+(4*4)+(3*6)+(2*3)+(1*6)=117
117 % 10 = 7
So 56046-36-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H3BrN4O/c6-5-9-2-3(10-5)7-1-8-4(2)11/h1-2H,(H,7,8,9,10,11)

56046-36-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-bromo-3,7-dihydropurin-6-one

1.2 Other means of identification

Product number -
Other names 8-bromohydropurin-6-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:56046-36-7 SDS

56046-36-7Downstream Products

56046-36-7Relevant articles and documents

Chemical radiation studies of 8-bromo-2′ -deoxyinosine and 8-bromoinosine in aqueous solutions

Russo, Marialuisa,Jimenez, Liliana B.,Mulazzani, Quinto G.,D'Angelantonio, Mila,Guerra, Maurizio,Miranda, Miguel A.,Chatgilialoglu, Chryssostomos

, p. 7684 - 7693 (2007/10/03)

The reactions of hydrated electrons (eaq-) with 8-bromo-2′-deoxyinosine (8) and 8-bromoinosine (12) have been investigated by radiolytic methods coupled with product studies and have been addressed computationally by means of BB1K-HMDFT calculations. Pulse radiolysis revealed that one-electron reductive cleavage of the C-Br bond gives the C8 radical 9 or 13 followed by a fast radical translocation to the sugar moiety. Selective generation of a C5′ radical occurs in the 2′-de-oxyribo derivative, whereas in the ribo analogue the reaction is partitioned between the C5′ and C2′ positions with similar rates. Both C5′ radicals undergo cyclizations, 10→11 and 14→15, with rate constants of 1.4 × 105 and of 1.3 × 104 s-1, respectively. The redox properties of radicals 10 and 11 have also been investigated. A synthetically useful photoreaction has also been developed as a one-pot procedure that allows the conversion of 8 to 5′,8-cyclo-2′- deoxyinosine in a high yield and a diastereoisomeric ratio (5′R)/ (5′S) of 4:1. The present results are compared with data previously obtained for 8-bromoadenine and 8-bromoguanine nucleosides. Theory suggests that the behavior of 8-bromopurine derivatives with respect to solvated electrons can be attributed to differences in the energy gap between the π*- and σ*-radical anions.

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