5606-55-3

Usage

Uses

Used in Pharmaceutical Industry:
Clonazepam is utilized as an anxiolytic agent for the treatment of anxiety disorders, providing relief from symptoms associated with excessive worry and fear. Its action on GABA receptors helps to calm the nervous system and reduce anxiety levels.
Used in Treatment of Panic Disorders:
Clonazepam serves as a therapeutic agent for panic disorder, a condition characterized by recurrent and unexpected panic attacks. By modulating the GABAergic system, it helps to alleviate the intense fear and physical symptoms associated with panic attacks.
Used in Management of Seizures:
Clonazepam is employed as an anticonvulsant medication for the management of various types of seizures. Its ability to enhance GABAergic neurotransmission helps to prevent the excessive electrical activity in the brain that leads to seizures.
Used in Combination Therapy:
Clonazepam may be used in combination with other medications for the treatment of certain conditions, such as epilepsy, where it can help to enhance the effectiveness of the primary antiepileptic drug.

InChI:InChI=1/C18H15ClN2O3/c1-2-24-18(23)16-17(22)20-14-9-8-12(19)10-13(14)15(21-16)11-6-4-3-5-7-11/h3-10,16H,2H2,1H3,(H,20,22)

Upstream product

• 62538-78-7 ethyl 2'-benzoyl-4'-chloro-mesoxalanilate 2-oxime 

Downstream Products

• 35142-51-9 10-chloro-11b-phenyl-2,3,5,11b-tetrahydrooxazolo[3,2-d] [1,4]benzodiazepin-6(7H)-one-5-carboxylic acid ethyl ester 
• 353524-67-1 C₁₈H₁₅ClN₂O₃ 
• 78817-83-1 C₁₈H₁₅ClN₂O₃ 
• 61294-98-2 7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid isopropyl ester 
• 88369-21-5 C₂₃H₁₈⁽²⁾HClN₂O₄S 
• 88369-19-1 7-chloro-5-phenyl-3-hydroxymethyl-3-deuterio-1,3-dihydro-2H-1,4-benzodiazepin-2-one 
• 88369-22-6 7-chloro-5-phenyl-3-methyl-2,2,3,3'-tetradeuterio-1,3-dihydro-2H-1,4-benzodiazepine 
• 88369-23-7 7-chloro-5-phenyl-3-methyl-3-deuterio-1,3-dihydro-2H-1,4-benzodiazepine 
• 317802-20-3 5-phenyl-7-chloro-3-benzyl-3-hydroxymethyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one 
• 317802-17-8 5-phenyl-7-chloro-3-benzyl-3-ethoxycarbonyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one 
• 213753-67-4 7-Chloro-3-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid ethyl ester 
• 27017-01-2 7-chloro-3-hydroxymethyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 88369-18-0 7-chloro-3-(ethoxycarbonyl)-5-phenyl-<3-2H₁>-1,3-dihydro-2H-1,4-benzodiazepin-2-one 

Relevant academic research and scientific papers

Preparation of benzodiazepine derivatives

A process for the manufacture of benzodiazepine derivatives which comprises reacting 2-amino-5-chloro-benzophenone with a primary amine H2 N--R1 to give an imine which is reacted with an amino-ester STR1 to give a ketimine said ketimine being then converted to a benzodiazepine derivative.

Intermediates for tricyclic benzodiazepines

Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.

Intermediates for preparing 1,4-benzodiazepine-2-ones having a carboxylic acid ester or amide group in the 3-position

Intermediates for preparing novel benzodiazepines having the formula SPC1 In which R1 is a hydrogen or halogen atom or a trifluoromethyl, loweralkyl, loweralkoxy, nitro or amino group; R2 is a furyl, a thienyl, cyclohexyl, a loweralkyl group or a phenyl group which may be substituted by a halogen atom or by a trifluoromethyl, nitro, loweralkoxy or loweralkyl group; and R3 is a hydrogen atom or a loweralkyl group; and R4 is lowercarbalkoxy, carbamoyl, N-loweralkylcarbamoyl, N,N-diloweralkylcarbamoyl, N-(diloweralkylaminoalkyl)carbamoyl, a group having the formula --COOCat in which Cat is a cation of an alkali metal or a semication of an alkaline earth metal or COOCat.CatOH, said intermediates being ortho-aminoaryl ketimines having the formula SPC2 Wherein R is hydrogen or EQU1 R1, R2, and R3 are as defined above, R4 is a hydrogen atom, a lowercarbalkoxy, carbamoyl, N-loweralkylcarbamoyl, N,N-diloweralkylcarbamoyl, N-(diloweralkylaminoalkyl)-carbamoyl, alkyl or substituted alkyl group; and R5 is a loweralkyl group.