56062-59-0

Usage

Uses

Used in Pharmaceutical Industry:
3-Azabicyclo[3.1.0]hexane-1-carbonitrile, 3-(phenylmethyl)is used as a building block for the development of new pharmaceutical compounds. Its unique structure and functional groups make it a promising candidate for the synthesis of various drug molecules.
Used in Organic Synthesis:
3-Azabicyclo[3.1.0]hexane-1-carbonitrile, 3-(phenylmethyl)serves as a precursor in the synthesis of complex organic compounds. Its reactivity and structural features allow for the formation of diverse chemical products, contributing to the advancement of organic chemistry.
Used in Research and Development:
3-Azabicyclo[3.1.0]hexane-1-carbonitrile, 3-(phenylmethyl)is utilized by researchers in the pharmaceutical and chemical industries for the exploration of its biological activity and potential applications. Its unique properties and reactivity make it an interesting subject for scientific investigation and innovation.

Synthetic route

N-Benzyl-N-(2-cyanoethyl)-2,3-dimethanesulfonylpropylamine → 3-benzyl-3-aza-bicyclo[3.1.0]hexane-1-carbonitrile (56062-59-0)

Conditions	Yield
With ammonium chloride; sodium hexamethyldisilazane In tetrahydrofuran; hexane; benzene

3-benzyl-3-aza-bicyclo[3.1.0]hexane-1-carbonitrile (56062-59-0) → 1-aminomethyl-3-benzyl-3-azabicyclo [3.1.0] hexane (134574-95-1)

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water	100%

3-benzyl-3-aza-bicyclo[3.1.0]hexane-1-carbonitrile (56062-59-0) → 3-benzyl-3-azabicyclo[3.1.0]hexane-1-carboxylic acid

Conditions	Yield
With barium dihydroxide In ethanol; water

Downstream Products

• 134574-95-1 N-3-benzyl-3-azabicyclo[3.1.0]hex-1-yl methylamine 

Relevant academic research and scientific papers

Azabicyclo quinolone carboxylic acids

Quinolone carboxylic acids 7-substituted by azabicyclo groups have antibacterial activity., Antibacterial wherein, R1 is hydrogen, a pharmaceutically acceptable cation, or alkyl;, Y, when taken independently, is ethyl, t-butyl, vinyl, cyclopropyl, 2-fluoroethyl, p-fluorophenyl, or o,p-difluorophenyl;, W is hydrogen, F, Cl, Br, alkyl, alkoxy, NH2, NHCH3;, A is CH, CF, CCl, COCH3, C-CH3, C-CN or N; or, A is carbon and is taken together with Y and the carbon and nitrogen to which A and Y are attached to form a five or six membered ring which may contain oxygen or a double bond, and which may have attached thereto R8 which is methyl or methylene; and, R2 is wherein R3, R4, R5, R6, R7, R9, R10 and R25 are each independently H, CH3, CH2NH2, CH2NHCH3 or CH2NHC2H5, and R5, R6, R7, and R9 may also independently be NH2, NHCH3 or NHC2H5.