56070-37-2

Usage

Uses

1. Used in Pharmaceutical Industry:
Methylb-neuraminicacidmethylester is used as a synthetic intermediate for the preparation of amide-linked sialooligomers, which are vital in the development of drugs targeting various diseases. Its role in creating these essential biomolecules makes it a significant component in the pharmaceutical industry.
2. Used in Chemical Synthesis:
As a naturally occurring alpha-Amino Acid, Methylb-neuraminicacidmethylester is used as a key building block in the synthesis of various chemical compounds. Its unique structure and properties allow it to be incorporated into a wide range of molecules, making it a versatile component in chemical research and development.
3. Used in Research and Development:
Methylb-neuraminicacidmethylester is utilized in research and development for its potential applications in creating novel compounds and materials. Its unique properties and reactivity make it an attractive candidate for exploring new avenues in scientific discovery.

Upstream product

• 186581-53-3 diazomethane 
• 56144-08-2 5-amino-O²-methyl-β-D-glycero-D-galacto-3,5-dideoxy-[2]nonulopyranosonic acid 
• 67-56-1 methanol 
• 19342-33-7 N-acetyl neuraminic acid 
• 67670-69-3 N-acetyl-4,7,8,9-tetra-O-acetyl-2-chloro-2-deoxyneuraminic acid methyl ester 
• 20298-35-5 N-acetylneuraminic acid methyl ester 

Downstream Products

• 1312776-91-2 N-(2-benzyloxy-2,2-[(2)H2]-acetyl)-2-O-methyl-β-neuraminic acid methyl ester 
• 1312777-08-4 2-benzyloxycarbonyl-N-([(2)H3]-acetyl)-β-neuraminic acid 1,7-lactone 
• 147072-99-9 methyl (benzyl 4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trifluoroacetamido-α-D-glycero-D-galacto-2-nonulopyranosid)onate 
• 1053260-72-2 (2S,4S,5R,6R)-5-Azido-6-[(1S,2R)-1,2-bis-(4-chloro-benzoyloxy)-3-hydroxy-propyl]-4-(4-chloro-benzoyloxy)-2-methoxy-tetrahydro-pyran-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

STRUCTURE OF THE CAPSULAR POLYSACCHARIDE OF Klebsiella ozaenae SEROTYPE K4 CONTAINING 3-DEOXY-D-glicero-D-galacto-NONULOSONIC ACID

The acidic capsular polysaccharide from the museum strain 2211 of Klebsiella ozaenae serotype K4 is built up of pentasaccharide repeating-units that contain residues of D-glucose, D-mannose, D-glucuronic acid, and 3-deoxy-D-glycero-D-galacto-nonulosonic acid (Kdn) in the ratios 2:1:1:1, as well as an O-acetyl group.The last-named sugar, which is reported in bacterial polysaccharides for the first time, was identified as the methyl (methyl 3-deoxynonulopyranosid)onate obtained by methanolysis of the polysaccharide.On the basis of the results of partial acid hydrolysis, Smith degradation, and computer-assisted 13C-n.m.r. analysis, it was concluded that the capsular polysaccharide has the following structure: .

Two procedures for the syntheses of labeled sialic acids and their 1,7-lactones

The synthesis of four deuterated sialic acids and their 1,7-lactones has been performed in two ways, one based on sialic acid classical chemistry, and the other involving a direct exchange of the unlabeled acyl group of N-acetylneuraminic acid with a labe

The thioglycoside and glycosyl phosphite of 5-Azido sialic acid: Excellent donors for the α-glycosylation of primary hydroxy groups

5-Azido sialyl donors with O-acetyl protecting groups are useful α-selective glycosylation reagents, especially for primary hydroxyl groups as acceptors. This is shown with a variety of reactions using 1 as a sialyl donor. It was also possible to synthesi

Determination of the Anomeric Configuration in Glycosides of 3-Deoxy-2-aldulosonic Acids by Circular Dichroism and X-Ray Crystallography

Methyl (methyl 3-deoxy-D-arabino-2-heptulopyranosid)onate was obtained by acid-catalysed esterification and glycosidation of the free 2-aldulosonic acid.The molecular geometry of the glycosidic ester was determined by X-ray crystallography, and indicated both that the molecule was α-anomer and that the ring oxygen and the carboxy-group were nearly coplanar.The c.d. spectrum showed a negative n -> ?* transition band centred at 224 nm.The c.d. spectra od a number of methyl glycopyranosides derived from 6-, 7-, and 8-carbon 3-deoxy-2-aldulosonic acids demonstrated that all the compounds believed to be α-glycosides had negative maxima, and all those believed to be β-glycosides had positive maxima around 220 nm independent of their 2C5 or5C2 conformation.The only known furanoside, believed to be a β-anomer, also had a positive maximum.The chirality of the anomeric carbon atom of this class of compound can thus be conveniently established by determining the sign of the Cotton effect at 220 nm.