56074-59-0Relevant academic research and scientific papers
Reaction of selenium dioxide with aromatic ketones in the presence of boron triflouride etherate: A protocol for the synthesis of triarylethanones
Laloo, Badaker M.,Mecadon, Hormi,Rohman, Md. Rumum,Kharbangar, Iadeishisha,Kharkongor, Icydora,Rajbangshi, Mantu,Nongkhlaw, Rishanlang,Myrboh, Bekington
experimental part, p. 707 - 712 (2012/02/16)
An efficient regioselective protocol for the C-C bond formation by the unexpected α,α-diarylation of aromatic ketones with unactivated arenes in the presence of selenium dioxide and boron trifluoride etherate has been developed. The generality and functio
Lewis acid-promoted friedel-crafts alkylation reactions with α-ketophosphate electrophiles
Smith, Austin G.,Johnson, Jeffrey S.
supporting information; experimental part, p. 1784 - 1787 (2010/09/05)
The BF3·OEt2-promoted nucleophilic substitution of α-aryl-α-ketophosphates to afford α,α-diaryl ketone products is described. Electron-rich α-ketophosphates perform best, with electron-neutral and electron-poor substrates also tolerated. The reaction is tolerant of a range of aromatic, heteroaromatic, and nonaromatic nucleophiles, with yields ranging from 44% to 84%. Enantioenriched starting material yields racemic product, suggesting an SN1 pathway via an acylcarbenium ion.
