56074-61-4

Upstream product

• 21669-52-3 1-(4-chloro-phenyl)-2,2-di-morpholin-4-yl-ethanone 
• 108-88-3 toluene 
• 611-97-2 bis(p-methylphenyl)-methanone 
• 885-77-8 4,4'-dimethylbenzhydrol 
• 106-38-7 para-bromotoluene 
• 52897-99-1 bromo(bis-p-tolyl)methane 
• 104-88-1 4-chlorobenzaldehyde 
• 104-87-0 4-methyl-benzaldehyde 

Relevant academic research and scientific papers

N-heterocyclic carbene-catalyzed cross-coupling of aromatic aldehydes with activated alkyl halides

N-Heterocyclic carbene-catalyzed umpolung of aldehydes followed by their interception with diarylbromomethanes has been reported. This conceptually novel transition-metal-free cross-coupling of aldehydes with alkyl halides works well at low catalyst loadings and under mild reaction conditions leading to the formation of diaryl acetophenone derivatives in good yields. In addition, α-halo ketones and esters can also be used as aldehyde reaction partners.

Reductive cross-coupling between N-acylbenzimidazoles and diarylketones promoted by Sm/TiCl4

The reductive cross-coupling reaction between N-acylbenzimidazoles and diarylketones promoted by Sm/TiCl4 was performed in refluxing THF under a nitrogen atmosphere, to give 1,2,2-triaryl ethanones in moderate to good yields.