56099-73-1

Upstream product

• 145472-46-4 (+/-)-1-(4-toluenesulfonyl)-piperidine-2-carbonitrile 
• 1221972-14-0 2-((E)-styryl)-1-(toluene-4-sulfonyl)-piperidine 
• 10285-80-0 N-tosyl-3-butenylamine 
• 1013212-43-5 C₁₄H₂₁NO₄S 
• 115344-32-6 (2S)-N-(1-benzyloxymethyl-3-hydroxypropyl)-4-methylbenzenesulfonamide 
• 919116-88-4 N-[1-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-propyl]-4-methyl-benzenesulfonamide 
• 919116-89-5 N-allyl-N-(1-benzyloxymethyl-3-hydroxy-propyl)-4-methyl-benzenesulfonamide 
• 919116-86-2 (2S)-N-allyl-N-(1-benzyloxymethyl-but-3-enyl)-4-methyl-benzenesulfonamide 
• 905859-22-5 4-benzyloxymethyl-3-(toluene-4-sulfonyl)-[1,3]oxazinan-6-one 
• 919116-87-3 (2S)-2-benzyloxymethyl-1-(4-methylphenylsulfonyl)-1,2,3,6-tetrahydropyridine 
• 919116-85-1 (2S)-N-allyl-N-[1-benzyloxymethyl-3-(t-butyldimethylsilanyloxy)propyl]-4-methylbenzenesulfonamide 
• 919116-90-8 N-allyl-N-(1-benzyloxymethyl-3-oxopropyl)-4-methylbenzenesulfonamide 
• 300594-05-2 4-[2-Oxo-3-(toluene-4-sulfonyl)-oxazolidin-(4E)-ylidene]-butyraldehyde 
• 912806-88-3 (S)-2-tosylamino-6,6-diethoxyhexanol benzyl ether 

Downstream Products

• 4043-87-2 pipecolic Acid 
• 3105-95-1 pipecolinic acid 
• 554434-26-3 (S)-1-(Toluene-4-sulfonyl)-piperidine-2-carboxylic acid ((S)-1-hydroxymethyl-2-phenyl-ethyl)-amide 

Relevant academic research and scientific papers

A concise and diastereoselective synthesis of piperidine and indolizidine alkaloids via aza-Prins cyclization

The synthesis of 2-substituted and 2,4-disubstituted piperidine alkaloids such as (±)-coniine, (±)-hydroxypipecolic acid, (±)-pipecolic acid, (±)-coniceine, and (±)-4-hydroxy-2- hydroxy-methyl piperidine have been accomplished in a highly diastereo-selective manner by employing aza-Prins cyclization as a key step to construct the piperidine core of these alkaloids. Georg Thieme Verlag Stuttgart · New York.

Complementary routes to both enantiomers of pipecolic acid and 4,5-dihydroxypipecolic acid derivatives

Complementary new routes to both enantiomers of N-protected pipecolic acid and the corresponding 4,5-dihydroxylated derivatives are developed, which involve stereo-divergent allylation of a chiral N-allylimine and ring-closing metathesis as key steps.

Nitrilase-catalyzed enantioselective synthesis of pyrrolidine- And piperidinecarboxylic acids

The enantioselective synthesis of the nonproteinogenic amino acids β-proline and nipecotic acids from their readily available nitriles is achieved in high enantiomeric excess by commercially available nitrilases. The presented procedure comprises not more than 4 steps, thus considerably reducing the multiple steps generally required. Amide formation is also observed for specific heterocyclic nitriles.

Synthesis of pipecolic acid and baikiain

A straightforward synthesis of pipecolic acid and baikiain was achieved from trans-(2S,4R)-4-hydroxyproline via the key steps of regioselective Baeyer-Villiger reaction. and ring-closing metathesis.

Highly enantioselective hydrogenation of exocyclic double bond of N-tosyloxazolidinones catalyzed by a neutral rhodium complex and its synthetic applications

A highly enantioselective synthesis of optically active N-tosyl-4-alkyl-1,3-oxazolidin-2-ones based on the asymmetric hydrogenation of the trisubstituted exocyclic double bond of N-tosyl-4-alkylidene-1,3-oxazolidin-2-ones under the catalysis of neutral [R

Peptidyl aldehyde inhibitors of calpain incorporating P2-proline mimetics

Four new peptidyl aldehydes bearing proline mimetics at the P2-position were synthesized and studied as inhibitors of calpain I, cathepsin B, and selected serine proteases. The ring size of the P2-constraining residue influenced the

Ketene-S,S-Acetals As 1,3-Dipolarophiles Towards Azides. A New Synthetic Entry Into Cyclic Amino Acids

Intramolecular azide cycloaddition reactions of ketene-S,S-acetals proceed to give a reactive imine as the initially-formed intermediate and this mechanism is supported by thermolysis of (18) which gave the stable imine (22).N-Acylation of this intermedia