561024-33-7

Basic information

• Product Name: (S)-1-(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-ethanol
• Synonyms: (S)-1-(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-ethanol
• CAS NO: 561024-33-7
• Molecular Weight: 217.311
• Mol File: 561024-33-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-ethanol(561024-33-7)
• EPA Substance Registry System: (S)-1-(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-ethanol(561024-33-7)

Safety Data

• Hazardous Substances Data: 561024-33-7(Hazardous Substances Data)

Upstream product

• 66842-22-6 (S)-1-(4-Pyridyl)ethylacetat 
• 54656-96-1 (S)-1-(4-pyridyl)ethanol 

Downstream Products

• 561024-36-0 N-[(S)-1-Benzyl-4-eth-(E)-ylidene-piperidin-3-yl]-2,2,2-trichloro-acetamide 
• 561024-37-1 (S)-1-Benzyl-4-eth-(E)-ylidene-piperidin-3-ylamine 
• 561024-38-2 (S)-1-Benzyl-4-ethyl-piperidin-3-ylamine 
• 688736-27-8 3(S),4(S)-cis-3-amino-4-ethylpiperidine 
• 561024-34-8 2,2,2-Trichloro-acetimidic acid (S)-1-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-ethyl ester 

Relevant articles and documents

Concise, enantiospecific synthesis of (3S,4R)-3-amino-4-ethylpiperidine as partner to a non-fluoroquinolone nucleus

An enantiospecific, eight-step synthesis of (3S,4R)-3-amino-4-ethylpiperidine 3 starting from readily available (S)-(-)-α-methyl-4-pyridinemethanol 6 has been achieved utilizing an Overman rearrangement of a chiral allylic trichloroacetimidate 13 as the key step. A diastereoselective hydrogenation of the resulting chiral allylic amine 15 afforded predominantly the desired trans-substituted piperidine. The conformation of the piperidine along with the directing nature of the amino function are implicated in the selectivity observed.