688736-27-8

Basic information

• Product Name: 3-Piperidinamine,4-ethyl-,(3R,4S)-rel-(9CI)
• Synonyms: 3-Piperidinamine,4-ethyl-,(3R,4S)-rel-(9CI)
• CAS NO: 688736-27-8
• Molecular Formula: C7H16N2
• Molecular Weight: 128.22
• Product Categories: AMINEPRIMARY
• Mol File: 688736-27-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Piperidinamine,4-ethyl-,(3R,4S)-rel-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Piperidinamine,4-ethyl-,(3R,4S)-rel-(9CI)(688736-27-8)
• EPA Substance Registry System: 3-Piperidinamine,4-ethyl-,(3R,4S)-rel-(9CI)(688736-27-8)

Safety Data

• Hazardous Substances Data: 688736-27-8(Hazardous Substances Data)

Upstream product

• 54656-96-1 (S)-1-(4-pyridyl)ethanol 
• 66842-22-6 (S)-1-(4-Pyridyl)ethylacetat 
• 561024-34-8 2,2,2-Trichloro-acetimidic acid (S)-1-(1-benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-ethyl ester 
• 561024-36-0 N-[(S)-1-Benzyl-4-eth-(E)-ylidene-piperidin-3-yl]-2,2,2-trichloro-acetamide 
• 561024-37-1 (S)-1-Benzyl-4-eth-(E)-ylidene-piperidin-3-ylamine 
• 561024-33-7 (S)-1-(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-ethanol 
• 561024-38-2 (S)-1-Benzyl-4-ethyl-piperidin-3-ylamine 

Relevant articles and documents

Concise, enantiospecific synthesis of (3S,4R)-3-amino-4-ethylpiperidine as partner to a non-fluoroquinolone nucleus

An enantiospecific, eight-step synthesis of (3S,4R)-3-amino-4-ethylpiperidine 3 starting from readily available (S)-(-)-α-methyl-4-pyridinemethanol 6 has been achieved utilizing an Overman rearrangement of a chiral allylic trichloroacetimidate 13 as the key step. A diastereoselective hydrogenation of the resulting chiral allylic amine 15 afforded predominantly the desired trans-substituted piperidine. The conformation of the piperidine along with the directing nature of the amino function are implicated in the selectivity observed.