561304-66-3

Upstream product

• 79-04-9 chloroacetyl chloride 
• 561304-65-2 2-amino-5-chlorophenyl 2-(trifluoromethoxy)phenyl ketone oxime 
• 18437-66-6 N-(t-butoxycarbonyl)-4-chloroaniline 
• 561304-62-9 tert-butyl N-[4-chloro-2-[α-hydroxy-α-(2-trifluoromethoxyphenyl)methyl]phenyl]carbamate 
• 561304-63-0 tert-butyl N-[4-chloro-2-[2-(trifluoromethoxy)benzoyl]phenyl]carbamate 
• 561304-64-1 2-amino-5-chlorophenyl 2-(trifluoromethoxy)phenyl ketone 
• 94651-33-9 2-(trifluoromethoxy)benzaldehyde 

Relevant academic research and scientific papers

Trifluoromethoxy substituted anilines: Metalation as the key step for structural elaboration

Trifluoromethoxy-substituted anilines undergo hydrogen/lithium permutation ("metalation") with optional site selectivity depending on the N-protective group employed. N-tert-Butoxycarbonyl-2-and -4-(trifluoromethoxy)aniline react with tert-butyllithium at