56141-11-8Relevant articles and documents
Modular counter-Fischer?indole synthesis through radical-enolate coupling
Chung, Hyunho,Kim, Jeongyun,Gonzalez-Montiel, Gisela A.,Cheong, Paul Ha-Yeon,Lee, Hong Geun
supporting information, p. 1096 - 1102 (2021/01/26)
A single-electron transfer mediated modular indole formation reaction from a 2-iodoaniline derivative and a ketone has been developed. This transition-metal-free reaction shows a broad substrate scope and unconventional regioselectivity trends. Moreover, important functional groups for further transformation are tolerated under the reaction conditions. Density functional theory studies reveal that the reaction proceeds by metal coordination, which converts a disfavored 5-endo-trig cyclization to an accessible 7-endo-trig process.
2,4,6-Halogeno-aniline derivatives
Ferguson, George,Low, John N.,Penner, Glenn H.,Wardell, James L.
, p. 1974 - 1977 (2007/10/03)
The title compounds, 2,4-dibromo-6-chloroaniline, C6H4-Br2ClN, (1), N-acetyl-4-bromo-2,6-dichloroaniline (alternative name: 4′-bromo-2′,6′-dichloroacetanilide), C8H6-BrCl2NO, (2), and N-formyl-4-bromo-2,6-difluoroaniline [alternative name: N-(4-bromo-2,6-difluorophenyl)formamide], C7H4BrF2NO, (3), all have at least one short cell axis (in the range 4.2-4.7 A) and contain molecules which are linked to form infinite chains along the short-axis directions via N-H...N or N-H...O hydrogen bonds. Compound (1) has halogen disorder at the 2 and 6 positions.
