56145-93-8

Basic information

• Product Name: N-[(2-hydroxyphenyl)carbonyl]-L-phenylalanine
• CAS NO: 56145-93-8
• Molecular Formula: C₁₆H₁₅NO₄
• Molecular Weight: 285.2946
• Mol File: 56145-93-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 552.6°C at 760 mmHg
• Flash Point: 288°C
• Density: 1.315g/cm³
• Vapor Pressure: 4.8E-13mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: N-[(2-hydroxyphenyl)carbonyl]-L-phenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(2-hydroxyphenyl)carbonyl]-L-phenylalanine(56145-93-8)
• EPA Substance Registry System: N-[(2-hydroxyphenyl)carbonyl]-L-phenylalanine(56145-93-8)

Safety Data

• Hazardous Substances Data: 56145-93-8(Hazardous Substances Data)

Upstream product

• 54539-61-6 2-hydroxybenzoyl azide 
• 63-91-2 L-phenylalanine 
• 5538-51-2 O-acetylsalicyloyl chloride 
• 70120-40-0 salicylic?acid?succinimidyl ester 
• 69-72-7 salicylic acid 
• 76748-72-6 aspirin phenylalanine ethyl ester 
• 109-86-4 2-methoxy-ethanol 
• 119697-50-6 2-(N-benzyloxycarbonyl-DL-phenylalanyloxy)-benzoic acid benzyl ester 
• 150-30-1 Phenylalanine 
• 56145-83-6 N-acetylsalicyloyl-L-phenylalanine benzyl ester 
• 1441-87-8 salicyloyl chloride 

Downstream Products

• 109094-46-4 N-(N-salicyloyl-DL-phenylalanyl)-glycine methyl ester 
• 63-91-2 L-phenylalanine 
• 69-72-7 salicylic acid 
• 56145-97-2 4-benzyl-2-(2-hydroxy-phenyl)-4H-oxazol-5-one 
• 101878-18-6 N-salicyloyl-phenylalanine methyl ester 

Relevant articles and documents

Is aspirin phenylalanine ethyl ester a prodrug for aspirin?

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A kinetic study into the hydrolysis of the ochratoxins and analogues by carboxypeptidase A

The hydrolyses of the ochratoxins and analogues by carboxypeptidase A were assessed. This was done by measuring the amount of phenylalanine formed with liquid chromatography coupled to tandem electrospray mass spectrometry. The kinetic data of ochratoxin A, ochratoxin B, and the synthetic bromo-ochratoxin B were compared to the values of a number of synthesized structure analogues, namely, ochratoxin A methyl ester, ochratoxin B methyl ester, N-(2-hydroxybenzoyl)phenylalanine, N-(5-chloro-2-hydroxybenzoyl)phenylalanine, N-(5-bromo-2-hydroxybenzoyl)phenylalanine, and N-(5-fluoro-2-hydroxybenzoyl)phenylalanine. The halogen-containing analogues had lower turnovers than their des-halo analogues. There are no substantial differences in the kinetic data between the different halogen-containing analogues.

Desferrioxamine oral delivery system

Modified amino acids and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. The modified amino acids are preparable by reacting single amino acids or mixtures of two or more kinds of amino acids with an amino modifying agent such as benzene sulfonyl chloride, benzoyl chloride, and hippuryl chloride. The modified amino acids may form encapsulating microspheres in the presence of the active agent under sphere-forming conditions. Alternatively, the modified amino acids may be used as a carrier by simply mixing the amino acids with the active agent. The preferred acylated amino acid carrier is salicyloyl-phenylalanine. The modified amino acids are particularly useful in delivering biologically active agents, e.g., desferrioxamine, insulin or cromolyn sodium, or other agents which are sensitive to the denaturing conditions of the gastrointestinal tract.