56146-52-2Relevant academic research and scientific papers
Antifungal Activity of 2,4-Dihydroxyacylophenones and Related Compounds
Mizobuchi, Shigeyuki,Sato, Yuko
, p. 1327 - 1334 (2007/10/02)
The antifungal activity of 2,4-dihydroxyacylophenones and related compounds against Trichophyton spp. and other fungi were investigated to determine their structure-activity relationships.The activity of these compounds was found to be closely related to the length of the acyl and alkyl substituents attached to the 1,3-dihydroxybenzene moiety.In addition, differences in activity were observed depending on the position of the alkyl substituents and on the number of substituents attached to the 1,3-dihydroxybenzene moiety.Some compounds tested showed potent antifungal activity against Trichophyton spp. and other fungi that was more active than amphotericin B.
