56146-83-9

Basic information

• Product Name: METHYL (CHLOROSULFONYL)ACETATE
• Synonyms: METHYL (CHLOROSULFONYL)ACETATE;Methyl 2-(Chlorosulfonyl)acetate;Acetic acid, (chlorosulfonyl)-, Methyl ester;(Methoxycarbonyl)methanesulfonyl chloride;2-Methoxy-2-oxoethanesulfonyl chloride;Chlorosulfonylacetic acid methyl ester;2-(chlorosulfonyl)Acetic acid methyl ester
• CAS NO: 56146-83-9
• Molecular Formula: C₃H₅ClO₄S
• Molecular Weight: 172.59
• Mol File: 56146-83-9.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 115-116℃ (15 Torr)
• Flash Point: 91.928 °C
• Appearance: /
• Density: 1.515 g/cm³
• Vapor Pressure: 0.074mmHg at 25°C
• Refractive Index: 1.466 (20℃)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly)
• Stability: Moisture Sensitive
• CAS DataBase Reference: METHYL (CHLOROSULFONYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (CHLOROSULFONYL)ACETATE(56146-83-9)
• EPA Substance Registry System: METHYL (CHLOROSULFONYL)ACETATE(56146-83-9)

Safety Data

• RIDADR: 3265
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 56146-83-9(Hazardous Substances Data)

Usage

General Description

Methyl (chlorosulfonyl)acetate is a chemical compound with the molecular formula C3H5ClO4S. It is a highly reactive and versatile compound that is used in various chemical reactions and organic synthesis processes. Methyl (chlorosulfonyl)acetate is known for its ability to act as a chlorinating, sulfonating, and esterifying reagent. It is commonly used in the production of pharmaceuticals, agrochemicals, and other fine chemicals. The compound is also used as a building block in the synthesis of various organic compounds and as a reagent in the preparation of specialty polymers. Due to its reactivity and versatile nature, it is important to handle methyl (chlorosulfonyl)acetate with caution and using appropriate safety measures.

InChI:InChI=1/C3H5ClO4S/c1-8-3(5)2-9(4,6)7/h2H2,1H3

Upstream product

• 67-56-1 methanol 
• 4025-77-8 chlorosulfonylacetyl chloride 
• 2365-48-2 Methyl thioglycolate 
• 96-32-2 bromoacetic acid methyl ester 
• 29508-16-5 sodium 2-methoxy-2-oxoethane-1-sulfonate 

Downstream Products

• 117765-69-2 (2-Nitro-phenylsulfamoyl)-acetic acid methyl ester 
• 126178-16-3 2-Benzyl-1,1-dioxo-3-phenyl-1λ⁶-[1,2]thiazetidine-4-carboxylic acid methyl ester 
• 13229-32-8 methyl 2‐(phenylsulfamoyl)acetate 
• 117765-67-0 methyl {[methyl(phenyl)amino]sulfonyl}acetate 
• 221249-46-3 9-<(1,1-dimethylethoxy)carbonyl>-3-thia-3,3-dioxo-4,9,13-triazatetradecanedioic acid, 14-(1,1-dimethylethyl) 1-methyl ester 
• 364614-32-4 methyl 2-(N-(4-methoxyphenyl)aminosulfonyl)acetate 
• 740834-98-4 methyl 2-(N-(4-bromophenyl)sulfamoyl)acetate 
• 200927-29-3 [[[6-(3-methyl-2-pyridinyl)-1,7-naphthyridin-8-yl]amino]sulfonyl]acetic acid, methyl ester 
• 291306-38-2 (ii)-Methyl 2-[(methylamino)sulphonyl]acetate 
• 130046-15-0 2-[N-(2,4,6 Trifluorophenyl)sulfamoyl]-acetic acid methyl ester 
• 130046-18-3 2-[N-(4-fluoro-2-trifluoromethylphenyl)sulfamoyl]-acetic acid methyl ester 
• 233283-83-5 C₁₈H₂₁NO₄S 
• 233283-91-5 C₁₉H₂₃NO₄S 
• 227304-76-9 C₂₀H₂₃NO₄S 

Relevant articles and documents

Clickable transformation of nitriles (RCN) to oxazolyl sulfonyl fluoride warheads

The protocol for simple, efficient, and mild synthesis of oxazolyl sulfonyl fluorides was developed through Rh2(OAc)4-catalyzed annulation of methyl-2-diazo-2-(fluorosulfonyl)acetate (MDF) or its ethyl ester derivative with nitriles. This practical method provides a general and direct route to a unique class of highly functionalized oxazolyl-decorated sulfonyl fluoride warheads with great potential in medicinal chemistry, chemical biology, and drug discovery.

Iridinesulfonamide compound and use method thereof

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DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS

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