56153-60-7

Usage

Uses

Used in Pharmaceutical Industry:
(2-Chlorophenyl)diphenylmethane is used as an active pharmaceutical ingredient for its antiproliferative properties. It is particularly effective in inhibiting the growth and proliferation of various types of cells, making it a promising candidate for the development of new drugs targeting specific conditions.
Used in Antifungal Applications:
(2-Chlorophenyl)diphenylmethane is used as an impurity in the antifungal agent Clotrimazole (C587400). Its presence in the compound contributes to the overall antifungal activity, helping to combat fungal infections and promote overall health.

Upstream product

• 50-00-0 formaldehyd 
• 66774-02-5 o-chlorotriphenylmethanol 
• 2206-27-1 dimethylsulfoxide-d6 
• 610-96-8 methyl chlorobenzoate 
• 23593-75-1 clotrimazole 
• 43014-48-8 1,2-bis-(2-chloro-phenyl)-2,2-diphenyl-ethanone 

Downstream Products

• 102948-87-8 2-(diphenylmethyl)benzophenone 
• 77539-21-0 9-ethyl-10-phenyl-anthracene 
• 13425-08-6 9-methyl-10-phenylanthracene 
• 1499-10-1 9,10-diphenylanthracene 
• 90292-76-5 2-benzhydryl-benzonitrile 

Relevant academic research and scientific papers

Triaryl methane derivatives as antiproliferative agents

Clotrimazole (CLT) 1, a synthetic anti-fungal imidazole derivative, inhibits tumor cell proliferation and angiogenesis. In the current study, flow cytometric analysis demonstrated that the decrease in tumor cell growth by CLT 1 was associated with inhibition of cell cycle progression at the G 1-S phase transition, resulting in G0-G1 arrest. A series of CLT 1 analogues has been generated in order to develop CLT 1 derivatives that are devoid of the imidazole moiety which is responsible for the hepatoxicity associated with CLT 1 while retaining CLT 1 efficacy. The majority of these analogues demonstrate in vitro antiproliferative activity ranging from submicromolar to micromolar concentrations.

Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction

The present invention relates to chemical compounds having inhibitory activity on an intermediate conductance Ca 2+ activated potassium channel (IK Ca), and the use of such compounds for the treatment or alleviation of diseases or conditions relating to immune dysfunction. Moreover, the invention relates to a method of screening a chemical compound for inhibitory activity on an intermediate conductance Ca 2+ activated potassium channel (IK Ca).

Use of triaryl methane compounds for inhibiting unwanted cellular proliferation associated with inflammatory disease

The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P, the compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.