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2206-27-1Relevant academic research and scientific papers
A Mechanistic Study of the Reaction of OH with Dimethyl-d6 Sulfide. Direct Observation of Adduct Formation and the Kinetics of the Adduct Reaction with O2
Hynes, A. J.,Stoker, R. B.,Pounds, A. J.,McKay, T.,Bradshaw, J. D.,et al.
, p. 16967 - 16975 (1995)
A pulsed laser photolysis-pulsed laser-induced fluorescence technique has been employed to study the detailed mechanism for the reaction of OH radicals with deuterated dimethyl sulfide .Equilibration of pulsed laser-generated OH with a (CD3)2S-OH adduct has been directly observed, thus confirming the existence of this controversial weakly bound species.Elementary rate coefficients for adduct formation and decomposition and, therefore, the equilibrium constant for OH + (CD3)S (CD3)2SOH have been determined as a function of temperature.From tte temperature dependence of the equilibrium constant over the relatively narrow temperature range 250-267 K, a 258 K adduct bond strength of 13.0 +/- 3.3 kcal mol-1 has been obtained (second law method).Alternatively, an entropy change calculated using standard statistical mechanical methods and ab initio theory (for determining the (CD3)2S and (CD3)2SOH structures) has been employed in conjunction with an experimental value for the equilibrium constant at a single temperature to obtain a 258 K adduct bond strength of 10.1 +/- 1.1 kcal mol-1 (third law method).Experiments in the presence of O2 confirm the previously reported dependence of the OH + DMS-d6 rate coefficient on the O2 partial pressure and are consistent with the previously proposed four-step mechanism involving hydrogen abstraction, addition of OH to the sulfur atom, and adduct decomposition in competition with an adduct + O2 reaction .The rate coefficient for the adduct + O2 reaction is found to be (8 +/-3 ) x 1E-13 cm3 molecule-1 s-1 independent of pressure (100-700 Torr of N2) and temperature (250-300 K).
Synthesis, reactivity and characterization of Pt(II) complexes with N,N′ chelating ligands; Structure and dimethylsulfoxide reactivity relationship
Ypsilantis, Konstantinos,Tsolis, Theodoros,Kourtellaris, Andreas,Manos, Manolis J.,Plakatouras, John C.,Garoufis, Achilleas
, p. 1467 - 1480 (2017/02/10)
Platinum(ii) complexes of the formula PtLCl2 [L = 2-(2′-pyridyl)quinoxaline, (pqx) (1), 2,(2′-pyridyl)benzo[g]quinoxaline, (pbqx) (3) and 2,(2′-pyridyl)quinoline, (pqn) (5)] were synthesized and characterized by spectroscopic and X-ray diffraction methods. Also, monodentate coordination of the ligands pqx and pbqx formed the complexes trans-Pt(DMSO)pqxCl2 (2) and trans-Pt(DMSO)pbqxCl2 (4) as it is indicated from X-ray crystal structure and NMR studies. The reaction of the complexes (1), (3) and (5) with DMSO-d6 revealed a ligand-release solvolysis, which was studied by means of NMR techniques. Correlation between the crystal structures of (1), (3), and (5) and the kinetic or thermodynamic parameters of the solvolysis reactions showed that the tendency of the ligands pqx, pbqx, and pqn to return to the anti-configuration in addition to their ability to form non-classical H-bonds are crucial factors for the ligand-release solvolysis. Instantaneous DMSO-d6 solvolysis for the complexes (1) and (3) and slow kinetics solvolysis for (5) (k = 10-4 ± 6.4 × 10-6 s-1) reflect their structural differences in ligand planarity. Based on NMR techniques a two-step mechanism of the chelate ring opening was suggested with equilibrium constants of the overall reaction at 298 K, Keq = 4.1 ± 0.2 × 10-4 M-1 (1) and Keq = 1.7 ± 0.2 × 10-4 M-1 (2).
ULTRAVIOLET RADIATION ABSORBING POLYETHERS
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Page/Page column, (2014/02/15)
A polymer composition comprising a linear ultraviolet radiation absorbing polyether that comprises a chemically bound UV-chromophore.
C-19 MODIFIED TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY
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Page/Page column, (2014/08/19)
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-19 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I and II: These compounds are useful for the treatment of HIV and AIDS.
POLYARYLENE POLYMERS AND PROCESSES FOR PREPARING
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, (2012/01/14)
Provided are sulfone-containing polyarylene polymers. Also provided are monomers and processes for preparing the polymers. The polyarylene polymers are suitable for use as engineering polymers.
Carbamoyl tetrahydropyridine derivatives
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, (2008/06/13)
Carbamoyl tetrahydropyridine derivatives represented by the formula: [in the formula, R1and R2are identical or different, and each represents a hydrogen atom, a C1-C5alkyl group, or the like; Y1-Y2represents (R4)C═C(R5), (R6)C═N, N═N, (R7)N—CO, or N═C(R8); X1, X2, and X3are identical or different, and each represents a hydrogen atom, a halogen atom, or the like; R3, R4, R5, and R6are identical or different, and each represents a hydrogen atom or an alkyl group; R7represents a hydrogen atom, a C1-C5alkyl group, or the like; and R8represents a hydrogen atom or a carbamoyl group] or a pharmaceutically acceptable salt thereof, and intermediates for the preparation thereof are provided. The derivatives described above are effective for diseases which are believed to involve CRF.
Methods for treatment of sickle cell anemia
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, (2008/06/13)
The preparation and use of a protected organic aldehyde is described wherein bioavailability of the orally administered therapeutic aldehyde is improved. The protected aldehyde is prepared by reacting the aldehyde with a protecting group, for example, condensing the aldehyde chemically with a thiazolidine-4-carboxylic acid. The improved bioavailability of such orally administered drugs increases the feasibility of delivering sufficient amounts of vanillin or other therapeutic organic aldehydes in vivo to prevent sickling in sickle cell anemia. Combination therapy is also described wherein a protected organic aldehyde is administered to a subject in treatment of sickle cell anemia in conjunction with one or more other drugs, such as pain killers, used in treatment of the symptoms of sickle cell anemia or sickle cell disease.
ENZYME DETECTION/ASSAY METHOD AND SUBSTRATES
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, (2008/06/13)
The invention relates to a method of detecting and/or assaying nucleoside hydrolases or nucleoside phosphorylases using a chromogenic substrate. Preferred chromogenic substrates have formula (I) where X is OH, or H, and Y is the residue of Y—OH where Y—OH is a chromophore or a compound readily converted to a chromophore and the substrates are hydrolysed by the nucleoside hydrolase to yield ribose or 2-deoxyribose plus Y—OH. Alternatively those substrates may be phosphorylysed by nucleoside phosphorylase to yield ribose-1-phosphate plus Y—OH. The methods may be used to detect and/or assay parasites in biological samples.
Bicyclic amino derivatives and PGD2 antagonist containing the same
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, (2008/06/13)
A compound of the formula (I): wherein for example, a compound below: whereinR1 is CH3, H or Na; and X1-X2-X3 is or its salt or a hydrate thereof is useful as PGD2 antagonist and can be used as a drug for treating diseases in which mast cell dysfunction is involved, for example, systemic mastocytosis and disorder of systemic mast cell activation, and also tracheal contraction, asthma, allergic rhinitis, allergic conjunctivitis, urticaria, injury due to ischemic reperfusion, and as an anti-inflammatory agent. It is particularly useful in the treatment of nasal occlusion.
Nitrogen containing heteroaromatics as factor Xa inhibitors
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, (2008/06/13)
The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.
